GRAFT-VERSUS-LEUKEMIA

作品数：4被引量：22H指数：2
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Haploidentical transplantation has a superior graft-versus-leukemia effect than HLA-matched sibling transplantation for Ph- high-risk B-cell acute lymphoblastic leukemia
《Chinese Medical Journal》2022年第8期930-939,共10页Fan Menglin Wang Yu Lin Ren Lin Tong Huang Fen Fan Zhiping Xu Yajing Yang Ting Xu Na Shi Pengcheng Nie Danian Lin Dongjun Jiang Zujun Wang Shunqing Sun Jing Huang Xiaojun Liu Qifa Xuan Li 
National Natural Science Foundation of China(Nos. 81770190, 81970161);National Key Research and Development Program of China(Nos. 2017YFA105500,2017YFA105504);Research and Development Program in Key Areas of Guangdong Province(No. 2019B020236004);Natural Science Foundation of Guangdong Province(No. 2019A1515011924);Project of the Zhujiang Science and Technology Star of Guangzhou City(No. 201806010029);Key Clinical Research Project of Southern Medical University(No. LC2016ZD009)。
Background: Compared with human leukocyte antigen (HLA)-matched sibling donor (MSD) transplantation, it remains unclear whether haploidentical donor (HID) transplantation has a superior graft-versus-leukemia (GVL) eff...
关键词：HAPLOIDENTICAL HLA-matched sibling Philadelphia-negative high-risk B-cell acute lymphoblastic leukemia GRAFT-VERSUS-LEUKEMIA TRANSPLANTATION 
Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation被引量：16
《Cellular & Molecular Immunology》2021年第5期1172-1185,共14页Huidong Guo Ying-Jun Chang Yan Hong Lan-Ping Xu Yu Wang Xiao-Hui Zhang Ming Wang Huan Chen Yu-Hong Chen Feng-Rong Wang Wei-Han Yu-Qian Sun Chen-Hua Yan Fei-Fei Tang Xiao-Dong Mo Kai-Yan Liu Xiao-Jun Huang 
supported by grants from the National Key Research and Development Program of China(2017YFA0104500);the Beijing Municipal Science and Technology Commission(Z181100009618032);the National Natural Science Foundation of China(Grant No.81621001,81530046,81770189,81670186,81870141 and 82070185);CAMS Innovation Fund for Medical Sciences(CIFMS)(grant number:2019-I2M-5-034);the Peking University Clinical Scientist Program(BMU2019LCKXJ003).
Haploidentical stem cell transplantation(haplo-SCT)achieves superior or at least comparable clinical outcomes to HLA-matched sibling donor transplantation(MSDT)in treating hematological malignancies.To define the unde...
关键词：GRAFT-VERSUS-LEUKEMIA Haplo-SCT MSDT AML MRD 
Nanoparticle-encapsulated allogeneic T cells mitigate graft-versus-host disease but retain graft-versus-leukemia activity
《中国药理学通报》2015年第B11期33-34,共2页
Aim Allogeneic hematopoietic stem cell transplantation （HSCT） has curable potential for hematopoietic malignancies through graft-versus-leukemia （GVL） effects but is often associated with life-threatening graft-ve...
关键词：NANOPARTICLE encapsulation T cells GRAFT-VERSUS-HOST disease GRAFT-VERSUS-LEUKEMIA immunoisola- tion 
Changes in the T-cell receptor Vβ gene repertoire after allogeneic hematopoietic stem cell transplantation被引量：6
《Chinese Medical Journal》2004年第3期413-418,共6页刘启发 李扬秋 杨冬 张钰 杨力建 陈少华 孙竞 刘晓力 周淑芸 
ThisstudywassupportedbytheNationalNatureScienceFoundationofChina (NO 3 9970 70 6)
Background We distinguished graft-versus-host disease (GVHD) from graft-versus-leukemia (GVL) effects and to investigate the distribution of T-cell receptor (TCR) Vβ gene repertoire in individuals with leukemia befor...
关键词：TCR Vβ gene repertoire · T cell clonality · hem atopoietic stem cell transplantation · graft-versus-host disease · graft-versus-leukemia 
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