METABOLOMIC

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Metabolomic Changes in Mice Induced by Copper Exposure:Systematic Analysis and Exploration of Toxicity Mechanisms
《Biomedical and Environmental Sciences》2025年第1期106-118,共13页Shuai Xiao Linqiang Gong Shiyuan Zhao Xue Chu Fengfeng Li Yazhou Zhang Fangqiang Song Pei Jiang Gang Ding Shuai Tang 
supported by grants from the Health Commission of Weifang(No.WFWSJK-2023-155 to Q.W.);the Natural Science Foundation of Shandong Province(No.ZR2024MH147 to G.D.);the National Natural Science Foundation of China(No.81570945 to G.D.).
Copper is one of the essential trace elements for living beings,influencing several critical processes like cellular energy production,antioxidant defense,communication within cells,and the functioning of enzymes[1].T...
关键词：COPPER HOMEOSTASIS thereby 
Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons
《Biomedical and Environmental Sciences》2024年第5期479-493,共15页LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing Ling PANG Shu Tao 
partly supported by grants from the National Natural Science Foundation of China(No:81372955);BiosTime Maternal and Infant Nutrition and Health Research Fund(2017FYH008);the Projects of Medical and Health Technology Development Program in Shandong Province(No:2016WS0309);Qingdao Outstanding Health Professional Development Fund(2020-2022,2022-2024)。
Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal m...
关键词：Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile 
Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors
《Biomedical and Environmental Sciences》2024年第2期133-145,共13页LIU Xiao CAO Ying LIN Xiao Wan GAO Dan Yang MIAO Hui Hui LI Tian Zuo 
funded by the Natural Science Foundation of Beijing(7212023);the National Natural Science Foundation of China(82071180)to HHM;the National Natural Science Foundation of China(82271206)to TZL。
Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ages.However,the underlying mechanism is yet unknown.Our study aimed to e...
关键词：METABOLOMIC Postoperative delirium(POD) Mechanism Biological marker 
Metabolomic Profiling of Mice Exposed toα-amanitin Using Ultra-performance Liquid Chromatography Quadrupole Time-of-flight Tandem Mass Spectrometry
《Biomedical and Environmental Sciences》2023年第3期289-294,共6页LI Lei ZHENG Chong YE Jian Fang ZHU Kai ZHOU Yi Bing LIU Jia GAO Ming WU Yu Tian LIU Yong Ting LIU Li Ya LIN Ye LI Hai Chang ZHANG Quan GUO Hua 
financially supported by Guizhou Provincial Science and Technology Support Program[No.Qiankehe[2021]496];Science and Technology Fund of Guizhou Health Commission[No.gzwkj2021-407];National Major Research Project[No.2017YFC1601805];Guizhou Provincial Science and Technology Support Program[No.Qiankehe[2017]2972]。
Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita fungi.Amatoxin is the main toxic compon...
关键词：Metab ani annually 
Serum Metabolomic Indicates Potential Biomarkers and Metabolic Pathways of Pediatric Kashin-Beck Disease被引量：1
《Biomedical and Environmental Sciences》2020年第10期750-759,共10页WANG Yu Meng WANG Wei Yi SUN Li Yan LI Qiang ZHAO Zhi Jun HU Jian ZHANG Rong Yu WANG Li Hua 
supported by the National Natural Science Foundation[NO.81372937]。
Objective To explore potential serum biomarkers of children with Kashin-Beck Disease(KBD)and the metabolic pathways to which the biomarkers belong.Methods A two-stage metabolomic study was employed.The discovery cohor...
关键词：Kashin-Beck disease Potential biomarkers Metabolism pathways SERUM 
Metabolomic Profiling Differences among Asthma,COPD,and Healthy Subjects:A LC-MS-based Metabolomic Analysis被引量：4
《Biomedical and Environmental Sciences》2019年第9期659-672,共14页LIANG Ying GAI Xiao Yan CHANG Chun ZHANG Xu WANG Juan LI Ting Ting 
funded by the National Natural Science Foundation of China-Youth Fund Project [No.81400017,81700039,81800038];the National Natural Science Foundation of China Emergency Management Project [No.81641153]
Objective Asthma and chronic obstructive pulmonary disease(COPD)feature different inflammatory and cellular profiles in the airways,indicating that the cellular metabolic pathways regulating these disorders are distin...
关键词：ASTHMA Chronic OBSTRUCTIVE pulmonary disease Metabolomics Liquid CHROMATOGRAPHY Mass SPECTROMETRY 
Metabolomic Study on Vitamins B_1, B_2, and PP Supplementation to Improve Serum Metabolic Profiles in Mice under Acute Hypoxia Based on ~1H NMR Analysis被引量：5
《Biomedical and Environmental Sciences》2010年第4期312-318,共7页JIN LIU JIAN-QUAN WU JI-JUN YANG JING-YU WEI WEI-NA GAO CHANG-JIANG GUO 
supported by a grant from the National Natural Science Foundation of China (NO. 30872097)
Objective To explore metabolic changes after acute hypoxia and modulating effect of vitamins B1, B2, and PP supplementation in mice exposed to acute hypoxia. Methods Fifty male Kunming mice were randomly divided into ...
关键词：Vitamins B1 B2 and PP Acute hypoxia 1H NMR MICE 
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