supported by the National Natural Science Foundation of China(Nos.22075049,22305042,22305041,21875043,22088101,21905052,and 51961145403);the National Key R&D Program of China(No.2018YFA0209401);the Key Basic Research Program of Science and Technology Commission of Shanghai Municipality(No.22JC1410200);the Natural Science Foundation of Shanghai(Nos.22ZR1478900 and 20490710600);the Shanghai Science and Technology Innovation Action Plan Morning Star Project(Sail Special,Nos.20QA1401200,22YF1402200,and 23YF1401900);the Shanghai Pilot Program for Basic Research-Fudan University(No.22TQ004);the Fundamental Research Funds for the Central Universities(No.20720220010).
Due to the amphiphilic nature of phospholipids in the cell membrane,the amphipathicity of the nanomedicine plays a crucial role in the endocytosis.However,limited biological characterization methods restrict the study...