SPIKE

作品数：309被引量：519H指数：9
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Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic
《Cell Research》2024年第10期739-742,共4页Can Yue Shuo Liu Bo Meng Kaiyue Fan Sijie Yang Pan Liu Qianhui Zhu Xin Mao Yuanling Yu Fei Shao Peng Wang Youchun Wang Ravindra Kumar Gupta Yunlong Cao Xiangxi Wang 
supported by the National Key R&D Program(2023YFC2306000 and 2018YFA0900801);the Ministry of Science and Technology of China(CPL-1233 and SRPG22-003),CAS(YSBR-010);the National Science Foundation Grants(12034006,32325004 and T2394482);supported by the National Science Fund for Distinguished Young Scholar(32325004);the NSFS Innovative Research Group(81921005).
Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has undergone continuous evolution since its initial outbreak in 2019.The emergence of Omicron as the dominant variant occurred abruptiy after 202...
关键词：sustained residue EXPANSION 
A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity
《Cell Research》2023年第12期975-978,共4页Yunping Ma Qiyu Mao Yingdan Wang Zhaoyong Zhang Jiali Chen Aihua Hao Palizhati Rehati Yanqun Wang Yumei Wen Lu Lu Zhenguo Chen Jincun Zhao Fan Wu Lei Sun Jinghe Huang 
supported by the National Natural Science Foundation of China(32370995 and 31771008 to J.H.and 3197014 to Z.C.);the Shanghai Municipal Science and Technology Major Project(ZD2021CY001 to J.H.);the Ministry of Science and Technology of China(2021YFC2302500 to L.S.);the National Youth Talent Support Program(2022 to F.W.);the“Shuguang Program”of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(22SG16 to F.W.);Guangzhou Laboratory(SRPG22-003 to L.S.);the National Science and Technology Major Projects of China(2017ZX10202102 to J.H.and 2018ZX10301403 to F.W.).
Dear Editor,Since the start of the COVID-19 pandemic,thousands of neutralizing antibodies(NAbs)targeting different epitopes of the spike protein have been identifed and characterized.1-3 However,the emergence of the O...
关键词：NEUTRAL sized HARBOR 
Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2被引量：1
《Cell Research》2022年第3期315-318,共4页Shuyuan Zhang Qingtai Liang Xinheng He Chongchong Zhao Wenlin Ren Ziqing Yang Ziyi Wang Qiang Ding Haiteng Deng Tong Wang Linqi Zhang Xinquan Wang 
We thank the Tsinghua University Branch of China National Center for Protein Sciences(Bejing)for technical support(Cryo EM,Protein Chemistry and Proteomics Facility Technology Center);This work was supported by funds from the National Natural Science Foundation of China(32171202);Tsinghua Unlversity Spring Breeze Fund(2020Z99CFY031).
Dear Editor,SARS-CoV-2 belongs to the Sarbecovirus subgenus of betacoronaviruses and other members in this subgenus include SARS-CoV and coronaviruses mainly found in bats1.It is generally believed that like SARS-CoV ...
关键词：RESERVOIRS belongs EVOLUTIONARY 
Author Correction: Mechanical activation of spike fosters SARS- CoV-2 infection
《Cell Research》2021年第11期I0003-I0003,共1页Wei Hu Yong Zhang Panyu Fei Tongtong Zhang Danmei Yao Yufei Gao Jia Liu Hui Chen Qiao Lu Tenny Mudianto Xinrui Zhang Chuxuan Xiao Yang Ye Qiming Sun Jing Zhang Qi Xie Pei-Hui Wang Jun Wang Zhenhai Li Jizhong Lou Wei Chen 
Mechanical activation of spike fosters SARS-CoV-2 viral infection被引量：4
《Cell Research》2021年第10期1047-1060,共14页Wei Hu Yong Zhang Panyu Fei Tongtong Zhang Danmei Yao Yufei Gao Jia Liu Hui Chen Qiao Lu Tenny Mudianto Xinrui Zhang Chuxuan Xiao Yang Ye Qiming Sun Jing Zhang Qi Xie Pei-Hui Wang Jun Wang Zhenhai Li Jizhong Lou Wei Chen 
We thank the Alibaba Cloud intelligence and the Baidu Cloud Engine for kindly providing the computational resources,Qiang Zhou from Westlake University for kindly providing SARS2-S expression plasmid,Xinghui Song from core facilities in Zhejiang University School of Medicine for FACS supports,and Kenneth Stapleford from New York University Grossman of Medicine for technical support.This work is supported by grants from the Ministry of Science and Technology of China(2017ZX10203205 to W.C.,2019YFA0707001 to J.Lou);the National Natural Science Foundation of China(32090044 and 11672317 to J.Lou,11772348 to Y.Z.,31971237 to W.C.);Zhejiang University special scientific research fund for COVID-19 prevention and control(2020XGZX077 to W.C.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37020102 to J.Lou);the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning(TP2018040 to Z.L.);the COVID-19 emergency tackling research project of Shandong University(2020XGB03 to P.-H.W.);an internal fund provided by the Office of Science&Research(OSR)and Department of Pathology,New York University Grossman School of Medicine to J.W.We also thank anonymous reviewers for very constructive suggestions and Dr.Jiajun Xu for valuable comments and revisions which improve our work significantly.
The outbreak of SARS-CoV-2(SARS2)has caused a global COVID-19 pandemic.The spike protein of SARS2(SARS2-S)recognizes host receptors,including ACE2,to initiate viral entry in a complex biomechanical environment.Here,we...
关键词：ACE2 INVASION ACTIVATION 
Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4被引量：29
《Cell Research》2013年第8期986-993,共8页Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang 
The spike glycoprotein （S） of recently identified Middle East respiratory syndrome coronavirus （MERS-CoV） tar- gets the cellular receptor, dipeptidyl peptidase 4 （DPP4）. Sequence comparison and modeling analysis...
关键词：MERS-CoV DPP4 RBD viral infection complex structure 
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