TIPPING

作品数：60被引量：75H指数：5
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Disease prediction by network information gain on a single sample basis
《Fundamental Research》2025年第1期215-227,共13页Jinling Yan Peiluan Li Ying Li Rong Gao Cheng Bi Luonan Chen 
supported by the National Natural Science Foundation of China(31930022,12131020,T2341007,T2350003);National Key R&D Program of China(2022YFA1004800);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38040400);Special Fund for Science and Technology Innovation Strategy of Guangdong Province(2021B0909050004,2021B0909060002);Key-Area Research and Development Program of Guangdong Province(2021B0909060002);MajorKey Project of PCL(PCL2021A12),and JST Moonshot R&D(JPMJMS2021).
There are critical transition phenomena during the progression of many diseases.Such critical transitions are usually accompanied by catastrophic disease deterioration,and their prediction is of significant importance...
关键词：Tipping point Network information gain Dynamic network biomarker Disease prediction Network flow entropy Drug target 
具有非平稳参数的二维肿瘤模型的B-tipping分析
《赣南师范大学学报》2024年第3期1-7,共7页袁娅茹 邱志鹏 
国家自然科学基金(12071217,12361098);江西省自然科学基金面上项目(20232BAB201024)。
本文建立了一个参数是非平稳变化过程的CD8+T细胞与肿瘤细胞相互作用的数学模型.首先对固定参数条件下的系统进行动力学分析,理论结果表明系统存在双稳态现象和鞍结点分岔.其后引入函数s(t)描述CD8+T细胞输入率的非平稳参数变化过程,发...
关键词：肿瘤模型 B-tipping point 双稳态 鞍结点 
Tipping Point Detection Using Reservoir Computing
《Research》2024年第1期779-790,共12页Xin Li Qunxi Zhu Chengli Zhao Xuzhe Qian Xue Zhang Xiaojun Duan Wei Lin 
the China Postdoctoral Science Foundation(no.2022M720817);by the Shanghai Postdoctoral Excellence Program(no.2021091);by the STCSM(nos.21511100200,22ZR1407300,and 23YF1402500);W.L.is supported by the National Natural Science Foundation of China(no.11925103);by the STCSM(nos.22JC1402500,22JC1401402,and 2021SHZDZX0103).
Detection in high fidelity of tipping points,the emergence of which is often induced by invisible changes in internal structures or/and external interferences,is paramountly beneficial to understanding and predicting ...
关键词：COMPUTING RECORD PING 
Do abrupt cryosphere events in High Mountain Asia indicate earlier tipping point than expected?被引量：2
《Advances in Climate Change Research》2023年第6期873-883,共11页Cun-De XIAO Tong ZHANG Tao CHE Zhi-Qiang WEI Tong-Hua WU Lei HUANG Ming-Hu DING Qiao LIU Dong-Hui SHANGGUAN Fei-Teng WANG Peng-Ling WANG Jie CHEN Chun-Hai XU Xin-Wu XU Da-He QIN 
supported by the National Key Research and Development Program of China (2022YFF0801903);the National Natural Science Foundation of China (41690145,42125604);the State Key Laboratory of Earth Surface Processes and Resource Ecology (2021-TS-06,2021-KF-06,and 2022-ZD-05);the Fundamental Research Funds for the Central Universities (2021NTST16);the Beijing Normal University Talent Introduction Project of China (12807-312232101);Basic Research Fund of CAMS (2023Z004).
Tipping points of about 16 elements have been identified in Earth system,yet cryospheric tipping point of specific Alpine region has not been studied.Here we analyzed three tipping elements(mountain glacier,snow cover...
关键词：Abrupt glacier change Thermakarst Snow depth Tipping point Early warning system 
Will the summer sea ice in the Arctic reach a tipping point?被引量：1
《Atmospheric and Oceanic Science Letters》2023年第3期58-62,共5页Ola M.Johannessen Elena V.Shalina 
funding support from the Nansen Scientific Society.
The Arctic sea-ice cover has decreased in extent,area,and thickness over the last six decades.Most global climate models project that the summer sea-ice extent(SIE)will decline to less than 1 million(mill.)km^(2) in t...
关键词：Sea ice ARCTIC Climate change Tipping point 
On the Image Reconstruction of Zhuge Liang in ACGN Games Based on the Perspective of the Tipping Point Theory
《Contemporary Social Sciences》2023年第1期116-130,共15页Li Hao Chen Haiyan Chang Baoqing 
The paper is a phased finding of the projects“Zhuge Liang and Studies of Shu-Han Classics”(20ZGL05);“Research on the Role of Domestic Online Games in Innovating and Communicating the Three Kingdoms Culture”(22ZGL02)granted by Zhuge Liang Research Center,a key research base of social sciences in Sichuan province。
Zhuge Liang,a well-known figure with rich cultural implications in Chinese history,has exerted profound influences on the spiritual life of the Chinese nation.In the ACGN context,new cultural implications have been at...
关键词：Zhuge Liang Three Kingdoms culture ACGN culture the tipping point the stickiness factor power of context 
Landscape dynamic network biomarker analysis reveals the tipping point of transcriptome reprogramming to prevent skin photodamage被引量：3
《Journal of Molecular Cell Biology》2021年第11期822-833,共12页Chengming Zhang Hong Zhang Jing Ge Tingyan Mi Xiao Cui Fengjuan Tu Xuelan Gu Tao Zeng Luonan Chen 
partially supported by the National Natural Science Foundation of China(31930022,31771476,12026608,12042104,and 11871456);the Strategic Priority Project of CAS(XDB38040400);the National Key R&D Program of China(2017YFA0505500);JST Moonshot R&D program(JP MJMS2021 to L.C.).
Skin,as the outmost layer of human body,is frequently exposed to environmental stressors including pollutants and ultraviolet(UV),which could lead to skin disorders.Generally,skin response process to ultraviolet B(UVB...
关键词：single-sample network tipping point UVB irradiation living skin equivalent model time series data skin lightening 
SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT被引量：6
《Science Bulletin》2020年第10期842-853,M0004,共13页Zhonglin Jiang Lina Lu Yuwei Liu Si Zhang Shuxian Li Guanyu Wang Peng Wang Luonan Chen 
supported by the National Key Research and Development Program of China (2017YFA0505500);the National Natural Science Foundation of China (31930022, 31771476, 61773196);Shanghai Municipal Science and Technology Major Project (2017SHZDZX01);Key Project of Zhangjiang National Innovation Demonstration Zone Special Development Fund (ZJ2018ZD-013);Ministry of Science and Technology Project (2017YFC0907505);Guangdong Provincial Key Laboratory Funds (2017B030301018, 2019B030301001);Shenzhen Research Funds (JCYJ20170307104535585, ZDSYS20140509142721429);Shenzhen Peacock Plan (KQTD2016053117035204)
Epithelial–mesenchymal transition(EMT) is a complex nonlinear biological process that plays essential roles in fundamental biological processes such as embryogenesis, wounding healing, tissue regeneration,and cancer ...
关键词：Dynamic network biomarker Tipping point Epithelial–mesenchymal transition BISTABILITY Quantitative real-time PCR 
Hunt for the tipping point during endocrine resistance process in breast cancer by dynamic network biomarkers被引量：9
《Journal of Molecular Cell Biology》2019年第8期649-664,共16页Rui Liu Jinzeng Wang Masao Ukai Ki Sewon Pei Chen Yutaka Suzuki Haiyun Wang Kazuyuki Aihara Mariko Okada-Hatakeyama Luonan Chen 
This work was supported by grants from the National Key R&D Program of China (2017YFA0505500);Strategic Priority Research Program of the Chinese Academy of Sciences (XDBl3040700);the National Natural Science Foundation of China (11771152,91529303,31771476,31571363,31771469,91530320,61134013,81573023,81501203,and 11326035);Pearl River Science and Technology Nova Program of Guangzhou (201610010029);FISRT,Aihara Innovative Mathematical Modeling Project from Cabinet Office,Japan;Fundamental Research Funds for the Central Universities (2017ZD095);JSPS KAKENHI (15H05707);Grant-in-Aid for Scientific Research on Innovative Areas (3901) and SPS KAKENHI (15KT0084,17H06299,17H06302,and 18H04031);RIKEN Epigenome and Single Cell Project Grants to M.O.-H.This work was performed in part under the International Cooperative Research Program of Institute for Protein Research,Osaka University (ICRa-17-01 to L.C.and M.O.-H.).
Acquired drug resistance is the major reason why patients fail to respond to cancer therapies.It is a challenging task to deter.mine the tipping point of endocrine resistance and detect the associated molecules.Derive...
关键词：drug resistance breast cancer TIPPING POINT dynamic NETWORK biomarker (DNB) molecular NETWORK MRNA-SEQ 
Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma被引量：14
《Science Foundation in China》2018年第3期31-31,共1页
With the support by the National Natural Science Foundation of China,the research team directed by Prof.Xia JingLin (夏景林)at the Liver Cancer Institute,Zhongshan Hospital,Fudan University,and Prof.Chen LuoNan at Sha...
关键词：动态网络 癌症 中国科学院 显示 科学基础 生物化学 复旦大学 研究所 
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