PROARRHYTHMIA

作品数：5被引量：16H指数：2
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Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts被引量：2
《Acta Pharmaceutica Sinica B》2022年第10期3905-3923,共19页Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto Jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan 
supported by the National University Heart Centre Singapore (NUHCS) Cardiovascular Research Institute (CVRI)Core Fund [Grant NUHSRO/2019/082/Core];SCEPTRE CG Seed Grant [Grant NMRC/CG/M008/2017, Singapore];Singapore Ministry of Education Tier 1 Academic Research Funding [Grant R-148-000-193-112];the National University of Singapore, Department of Pharmacy, Final Year Project Funding [Grant C148-000-003-001] provided to Eric Chun Yong Chan;from Japan Society for the Promotion of Science (JSPS) KAKENHI [grant number 20K16136] provided to Ryuichi Kambayashi
Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adver...
关键词：Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids Mechanism-based inactivation DRONEDARONE 
Flecainide: Current status and perspectives in arrhythmia management被引量：9
《World Journal of Cardiology》2015年第2期76-85,共10页George K Andrikopoulos Sokratis Pastromas Stylianos Tzeis 
Flecainide acetate is a class IC antiarrhythmic agent and its clinical efficacy has been confirmed by the results of several clinical trials. Nowadays, flecainide is recommended as one of the first line therapies for ...
关键词：FLECAINIDE Class IC ANTIARRHYTHMIC drugs Atrial FIBRILLATION Ventricular TACHYCARDIA PROARRHYTHMIA 
Ibutilide and novel indexes of ventricular repolarization in persistent atrial fibrillation patients被引量：3
《World Journal of Cardiology》2013年第7期242-246,共5页Panagiotis Korantzopoulos Konstantinos P Letsas Anna Kotsia Giannis Baltogiannis Kallirroi Kalantzi Konstantinos Kyrlas John A Goudevenos 
AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion...
关键词：IBUTILIDE VENTRICULAR REPOLARIZATION Arrhythmic risk PROARRHYTHMIA Dispersion of REPOLARIZATION T peak-to-end T peak-to-end/QT ratio 
Mechanisms of drug-induced proarrhythmia in clinical practice被引量：2
《World Journal of Cardiology》2013年第6期175-185,共11页Arkadia Konstantopoulou Spyros Tsikrikas Dimitrios Asvestas Panagiotis Korantzopoulos Konstantinos P Letsas 
Drug-induced proarrhythmia represents a great challenge for those involved in the development of novel pharmaceuticals and in the regulatory bodies for drug approval as well as for the prescribing clinicians.Our under...
关键词：Drugs SUDDEN cardiac death Long QT SYNDROME Short QT SYNDROME BRUGADA SYNDROME 
Potential proarrhythmic effect of cardiac resynchronization therapy during perioperative period： data from a single cardiac center
《Chinese Medical Journal》2010年第17期2295-2298,共4页LUO Nian-sang YUAN Wo-liang LIN Yong-qing CHEN Yang-xin MAO Xiao-qun XIE Shuang-lun KONG Min-yi ZHOU Shu-xian WANG Jing-feng 
Background Cardiac resynchronization therapy （CRT） could improve heart function, symptom status, quality of life and reduce hospitalization and mortality in patients with severe heart failure （HF） with optimal med...
关键词：chronic heart failure biventricular pacing cardiac resynchronization therapy PROARRHYTHMIA 
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