Γ-SECRETASE

作品数：23被引量：59H指数：5
导出分析报告
相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 主题=PRESENILINx
共 条 记 录，以下是1-3
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
《Neural Regeneration Research》2022年第1期31-37,共7页Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre 
supported by the Consejo Nacional de Ciencia y Tecnología Scholarship 711893(to MAH)and 711874(to EER)。
The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressiv...
关键词：familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex 
Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models被引量：1
《Translational Neurodegeneration》2019年第1期433-449,共17页Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler 
This work has been developed and supported through the LABEX(excellence laboratory,program investment for the future)DISTALZ(Development of lnnovative Strategies for a Transdisciplinary approach to ALZheimers disease)and by Fondation Alzheimer.A.Be and A.Bo were granted from DISTALZ.
Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with th...
关键词：Extracellular vesicles C99 APP-CTFs Homo-and hetero-oligomerization ENDOSOMES LYSOSOMES trans-Golgi network SorLA γ-Secretase inhibition Presenilin knockout Alzheimer’s disease 
Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice被引量：1
《Acta Biochimica et Biophysica Sinica》2015年第4期258-266,共9页Yanan Chu Xuehua Peng Zhiming Long Kejian Wang Shifang Luo Akhilesh Sharma Guiqiong He 
This work was supported by the grants from the National Natural Science Foundation of China （Nos. 81371221 and 30700885） and the Program for New Century Excellent Talents in University （No. NCET-11-1084）.
The γ-secretase complex catalyzes the final cleavage step of amyloid β-protein precursor （APP） to generate amyloid β （Aβ） peptide, a pathogenic component of senile plaques in the brain of AIzhei- mer＇s disea...
关键词：presenilin enhancer-2 Γ-SECRETASE Alzheimer＇s disease central nervous system DISTRIBUTION 
全选清除导出
共1页<1>
检索报告 对象比较 聚类工具 使用帮助 返回顶部