Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease
《Neural Regeneration Research》2025年第1期174-180,共7页Yinglong Miao Michael S.Wolfe 
supported in part by Award 2121063 from National Science Foundation(to YM);AG66986 from the National Institutes of Health(to MSW).
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...
关键词：Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics NOTCH 
Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells被引量：9
《World Journal of Gastroenterology》2015年第33期9727-9735,共9页Bing Han Shi-Hai Liu Wei-Dong Guo Bin Zhang Jian-Ping Wang Yu-Kun Cao Jun Liu 
Supported by Shandong Provincial Natural Science Foundation,China,No.ZR2012HQ039 and No.ZR2014HP065;National Natural Science Foundation of China,No.81373172 and No.81402579
AIM: To confirm the anti-invasion and anti-migration effects of down-regulation of Notch1 combined with interleukin(IL)-24 in hepatocellular carcinoma(HCC) cells.METHODS: γ-secretase inhibitors(GSIs) were used to dow...
关键词：NOTCH signaling pathway INTERLEUKIN-24 Γ-SECRETASE 
γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats被引量：14
《Chinese Medical Journal》2014年第5期924-928,共5页Huang Man Liu chunhui Hu Yueyu Wang Pengfei Ding Meiping 
Background Brain dysfunction is a frequent complication of sepsis,usually defined as sepsis-associated encephalopathy （SAE）.Although the Notch signaling pathway has been proven to be involved in both ischemia and ne...
关键词：DAPT Γ-SECRETASE memory impairment SEPSIS NOTCH 
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