INTERLEUKIN-24

作品数：10被引量：34H指数：4
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相关领域：医药卫生更多>>
相关作者：侯文娜何生姜增誉王朝霞更多>>
相关机构：山西医科大学第一医院山西医科大学更多>>
相关期刊：《肿瘤研究与临床》《Reproductive and Developmental Medicine》《World Journal of Gastroenterology》《Hepatobiliary & Pancreatic Diseases International》更多>>
相关基金：国家自然科学基金湖北省自然科学基金年山西省研究生优秀创新项目更多>>
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CCL2 Enhances the Viability of Human Chorionic Trophoblast Cell Line HTR-8/SVneo Cells by Inhibiting Interleukin-24 Expression
《Reproductive and Developmental Medicine》2017年第4期198-203,共6页Jun Shao Yin-Yan He Da-Jin Li Ming-Qing Li 
This study was supported by the National Natural Science Foundation of China(NSFC)(81571509,31671200);the Program for Zhuoxue of Fudan University.
Background:To investigate the regulatory effect of interleukin-24(IL-24)on cell viability of human chorionic trophoblast cell line(HTR-8/SVneo cells).Methods:Immunohistochemical staining was used to detect the express...
关键词：CCL2 Cell Viability Chorionic Trophoblasts HTR-8/SVneo Cells INTERLEUKIN-24 
多功能抗癌基因白细胞介素24在肿瘤中的研究进展被引量：1
《肿瘤研究与临床》2016年第2期136-140,共5页姜增誉 侯文娜 何生 
山西省研究生创新基金(2012038)；山西医科大学创新基金(01201316)Fund program:Shanxi Graduate Student Innovation Foundation，Shanxi Medical University Innovation Foundation
白细胞介素24（IL-24）是通过消减杂交法从人黑色素瘤细胞中分离出来的黑色素瘤分化相关基因，属于IL-10家族，它有促进肿瘤细胞凋亡、抑制血管形成、增强放化疗敏感性以及免疫调节等作用，而对正常细胞没有毒副作用。作为一种具有多种...
关键词：白细胞介素24 肿瘤 细胞凋亡 基因 INTERLEUKIN-24 
Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells被引量：9
《World Journal of Gastroenterology》2015年第33期9727-9735,共9页Bing Han Shi-Hai Liu Wei-Dong Guo Bin Zhang Jian-Ping Wang Yu-Kun Cao Jun Liu 
Supported by Shandong Provincial Natural Science Foundation,China,No.ZR2012HQ039 and No.ZR2014HP065;National Natural Science Foundation of China,No.81373172 and No.81402579
AIM: To confirm the anti-invasion and anti-migration effects of down-regulation of Notch1 combined with interleukin(IL)-24 in hepatocellular carcinoma(HCC) cells.METHODS: γ-secretase inhibitors(GSIs) were used to dow...
关键词：NOTCH signaling pathway INTERLEUKIN-24 Γ-SECRETASE 
Improving the mda-7/IL-24 refolding and purification process using optimized culture conditions based on the structure characteristics of inclusion bodies
《Bioresources and Bioprocessing》2014年第1期82-90,共9页Xiaojuan Wang Chaogang Bai Jian Zhang Aiyou Sun Xuedong Wang Dongzhi Wei 
supported by a grant from the Ministry of Science and Technology(National Major Science and Technology Projects of China(No.2012ZX09304009)).
Background:The melanoma differentiation-associated gene-7(mda-7)/interleukin-24(IL-24)can induce apoptosis in a wide variety of tumor cell types,whereas it has no toxicity in normal cells.However,recombinant human mda...
关键词：Escherichia coli EXPRESSION Inclusion body INTERLEUKIN-24 PURIFICATION REFOLDING 
Cancer targeting Gene-Viro-Therapy specific for liver cancer by α-fetoproteincontrolled oncolytic adenovirus expression of SOCS3 and IL-24被引量：1
《Acta Biochimica et Biophysica Sinica》2011年第10期813-821,共9页Xin Cao Ruicheng Wei Xinran Liu Yan Zeng Hongling Huang Miao Ding Kangjian Zhang Xin-Yuan Liu 
The combination of gene therapy and virotherapy for cancer treatment has received close attention and has become a trend in the field of cancer biotherapy. A strat- egy called ＇Cancer Targeting Gene-Viro-Therapy＇ （...
关键词：cancer biotherapy oncolytic adenovirus APOPTOSIS suppressor of cytokine signaling 3 INTERLEUKIN-24 
Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer被引量：3
《World Journal of Gastroenterology》2011年第9期1167-1173,共7页Youngmin Choi Mee-Sook Roh Young-Seoub Hong Hyung-Sik Lee Won-Joo Hur 
Supported by Dong-A University Research Fund
AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with ly...
关键词：INTERLEUKIN-24 Rectal cancer Lymph node Histological differentiation Vascular endothelial growth factor 
Oncolytic adenovirus-mediated MDA-7/IL-24 overexpression enhances antitumor activity in hepatocellular carcinoma cell lines被引量：8
《Hepatobiliary & Pancreatic Diseases International》2010年第6期615-621,共7页Xiao, Chao-Wen Xue, Xin-Bo Zhang, Hui Gao, Wei Yu, Yuan Chen, Kun Zheng, Jian-Wei Wang, Cong-Jun 
supported by a grant from the National Natural Science Foundation of China(30872510)
BACKGROUND: Melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24) is a novel tumor suppressor gene, which has suppressor activity in a broad spectrum of human cancer cells. We investigated the effe...
关键词：melanoma differentiation-associated gene-7 INTERLEUKIN-24 oncolytic adenovirus hepatocellular carcinoma gene therapy 
Oncolytic adenovirus SG600-IL24 selectively kills hepatocellular carcinoma cell lines被引量：3
《World Journal of Gastroenterology》2010年第37期4677-4684,共8页Xin-Bo Xue  Chao-Wen Xiao Hui Zhang  Ai-Guo Lu  Wei Gao  Zhu-Qing Zhou  Xin-Lai Guo  Ming-An Zhong  Yao Yang  Cong-Jun Wang 
Supported by National Natural Science Foundation of China,No. 30872510;Natural Science Foundation of Hubei Province,No. 2008CDB127
AIM: To investigate the effect of oncolytic adenovirus SG600-IL24 and replication-incompetent adenovirus Ad.IL-24 on hepatocellular carcinoma (HCC) cell lines and normal liver cell line. METHODS: HCC cell lines (HepG2...
关键词：Oncolytic adenovirus Hepatocellular carcinoma Cancer gene therapy p53-independent Melanoma differentiation-associated-7/interleukin-24 
Targeted IL-24 gene therapy inhibits cancer recurrence after liver tumor resection by inducing tumor cell apoptosis in nude mice被引量：5
《Hepatobiliary & Pancreatic Diseases International》2009年第2期174-178,共5页Yang, Yong-Jiu Chen, Da-Zhi Li, Li-Xin Sheng, Qin-Song Jin, Zhong-Kui Zhao, De-Fang 
BACKGROUND: Interleukin-24 (IL-24) is a novel candidate tumor suppressor that induces tumor cell apoptosis experimentally in a variety of human malignant cells including liver cancer cells. The present study was condu...
关键词：liver neoplasms gene therapy INTERLEUKIN-24 apoptosis 
Effect of recombinant adenovirus vector mediated human interleukin-24 gene transfection on pancreatic carcinoma growth被引量：8
《Chinese Medical Journal》2008年第20期2031-2036,共6页PAN Xin-ting ZHU Qing-yun LI De-chun YANG Ji-cheng ZHANG Zi-xiang ZHU Xing-guo ZHAO Hua 
This work was supported by a grant from the Science Foundation of the Ministry of Health of China （No. WKJ2004-2-011）.
Background Pancreatic cancer is a highly malignant tumor affecting an ever increasing number of patients with a mean 5-year survival rate below 4%. Therefore, gene therapy for cancer has become a potential novel thera...
关键词：INTERLEUKIN-24 ADENOVIRUS pancreatic carcinoma gene therapy ANGIOGENESIS apoptosis 
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