Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
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Critical thinking on amyloid-beta-targeted therapy:challenges and perspectives被引量：8
《Science China(Life Sciences)》2021年第6期926-937,共12页Bin-Lu Sun Yang Chen Dong-Yu Fan Chi Zhu Fan Zeng Yan-Jiang Wang 
supported by the National Natural Science Foundation of China(91749206,81930028,81625007,81870860,31921003)。
Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimer's disease(AD)and has been regarded as the main therapeutic target for AD.However,most of the Aβ-targeted clinical trials have not succeeded.There...
关键词：Alzheimer's disease amyloidβ immunotherapy Β-SECRETASE Γ-SECRETASE enzyme inhibitor multi-target therapy tertiary prevention strategy 
Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene and protein expression in BV2 cells
《Neural Regeneration Research》2014年第21期1923-1928,共6页Guangzhe Li Hui Chen Lin Cheng Rongjie Zhao Junchang Zhao Yanji Xu 
supported by the Natural Science Foundation of Technology Gallery in Jilin Province of China,No.2011-15237;the National Natural Science Foundation of China,No.81160159
The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secret-ing inlfammatory cytokines, and is an important target in the treatment of nerve inlfammation and neurodegenerative di...
关键词：nerve regeneration NEURODEGENERATION Alzheimer’s disease APLP2 S100A9 C-terminal fragments amyloid precursor protein BV2 cells Γ-SECRETASE NSFC grant neural regeneration 
β-Arrestinl regulates γ-secretase complex assembly and modulates amyloid-β pathology被引量：1
《Cell Research》2013年第3期351-365,共15页Xiaosong Liu Xiaohui Zhao Xianglu Zeng Koen Bossers Dick F Swaab Jian Zhao Gang Pei 
Alzheimer＇s disease （AD） is a progressive and complex neurodegenerative disease in which the γ-secretase- mediated amyloid-β （Aβ） pathology plays an important role. We found that a multifunctional protein, β-...
关键词：Alzheimer＇s disease β-arrestinl APH- 1 Γ-SECRETASE 
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