Γ-SECRETASE

作品数:23被引量:59H指数:5
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相关领域:医药卫生更多>>
相关作者:殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构:东南大学清华大学第二军医大学台湾大学更多>>
相关期刊:《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金:国家自然科学基金World Health Organization更多>>
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γ-Secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway
《Acta Pharmacologica Sinica》2014年第6期825-831,共7页Jun-yang LI Ru-jun LI Han-dong WANG 
Acknowledgements We thank Prof Bruce D HAMMOCK for providing the sEH inhibitor t-AUCB. This study was supported by the National Natural Science Foundation of China (No 81070974 and No 81301905).
Aim: Trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB) is a soluble epoxide hydrolase inhibitor that suppresses glioblastoma cell growth in vitro. The aim of this study was to examine whet...
关键词:GLIOMA chemotherapy Γ-SECRETASE DAPT soluble epoxide hydrolase t-AUCB apoptosis caspase-3 p38 MAPK MAPKAPK2 HSP27 
γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats被引量:14
《Chinese Medical Journal》2014年第5期924-928,共5页Huang Man Liu chunhui Hu Yueyu Wang Pengfei Ding Meiping 
Background Brain dysfunction is a frequent complication of sepsis,usually defined as sepsis-associated encephalopathy (SAE).Although the Notch signaling pathway has been proven to be involved in both ischemia and ne...
关键词:DAPT Γ-SECRETASE memory impairment SEPSIS NOTCH 
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