This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81371221 and 30700885) and the Program for New Century Excellent Talents in University (No. NCET-11-1084).
The γ-secretase complex catalyzes the final cleavage step of amyloid β-protein precursor (APP) to generate amyloid β (Aβ) peptide, a pathogenic component of senile plaques in the brain of AIzhei- mer's disea...
the Natural Science Foundation of Bei-jing, No. 7073088
BACKGROUND: Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer's disease, and β- and y-secretase play an important role in the generation of β-amyloid protein. ...