Γ-SECRETASE

作品数:23被引量:59H指数:5
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相关领域:医药卫生更多>>
相关作者:殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构:东南大学清华大学第二军医大学台湾大学更多>>
相关期刊:《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金:国家自然科学基金World Health Organization更多>>
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Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice被引量:1
《Acta Biochimica et Biophysica Sinica》2015年第4期258-266,共9页Yanan Chu Xuehua Peng Zhiming Long Kejian Wang Shifang Luo Akhilesh Sharma Guiqiong He 
This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81371221 and 30700885) and the Program for New Century Excellent Talents in University (No. NCET-11-1084).
The γ-secretase complex catalyzes the final cleavage step of amyloid β-protein precursor (APP) to generate amyloid β (Aβ) peptide, a pathogenic component of senile plaques in the brain of AIzhei- mer's disea...
关键词:presenilin enhancer-2 Γ-SECRETASE Alzheimer's disease central nervous system DISTRIBUTION 
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rats
《Neural Regeneration Research》2010年第5期353-357,共5页Xiaojuan Wang Hong Liu Liang Li 
the Natural Science Foundation of Bei-jing, No. 7073088
BACKGROUND: Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer's disease, and β- and y-secretase play an important role in the generation of β-amyloid protein. ...
关键词:chronic cerebral hypoperfusion Β-AMYLOID Β-SECRETASE Γ-SECRETASE Alzheimer's disease brain injury neural regeneration 
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