云南高校图书馆联盟文献共享服务平台- EXON

EXON: 作品数：161被引量：414H指数：11; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：贾天军赵铁军张庶民李萍金鑫燕更多>>; 相关机构：河北北方学院中国药品生物制品检定所青海大学南京军区福州总医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家高技术研究发展计划河北省自然科学基金国家科技支撑计划更多>>

Gastrointestinal stromal tumors with an uncommon primary mutation responded well to imatinib: 《Cancer Pathogenesis and Therapy》2025年第2期176-178,共3页Gilani Shahid Mujeeb Qudsia Ikram Naima Khir Ibrahim; Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract,driven by mutations in the proto-oncogene c-KIT or platelet-derived growth factor alpha(PDGFRA)gene in 85%-90%...; 关键词：exon mutation mesenchymal tumors tyrosine kinase inhibitor tki gastrointestinal stromal tumors IMATINIB partial response gastrointestinal stromal tumors gists

Significance of monitoring imatinib plasma concentration in secondline treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors: 《World Journal of Gastrointestinal Oncology》2025年第3期81-90,共10页Hai-Tao Li Yun-Yun Du Zhen Huang Jin-Jin Li Jun Zhang; BACKGROUND For patients with advanced gastrointestinal stromal tumors(GISTs)carrying the ckit exon 11 mutation,imatinib(IM)at a standard dosage of 400 mg per day is the preferred first-line treatment.In cases where tr...; 关键词：Gastrointestinal stromal tumor C-kit exon 11 IMATINIB Plasma concentration Second-line treatment

Dysregulated inclusion of BOLA3 exon 3 promoted by HNRNPC accelerates the progression of esophageal squamous cell carcinoma: 《Frontiers of Medicine》2024年第6期1035-1053,共19页Bo Tian Yan Bian Yanan Pang Ye Gao Chuting Yu Xun Zhang Siwei Zhou Zhaoshen Li Lei Xin Han Lin Luowei Wang; supported by Shanghai Science and Technology Innovation Action Program(No.21Y31900100).; Dysregulated RNA splicing events produce transcripts that facilitate esophageal squamous cell carcinoma(ESCC)progression,but how this splicing process is abnormally regulated remains elusive.Here,we unveiled a novel a...; 关键词：esophageal squamous cell carcinoma alternative splicing exon skipping BOLA3 HNRNPC

Truncated SCRIB isoform promotes breast cancer metastasis through HNRNP A1 mediated exon 16 skipping: 《Acta Pharmacologica Sinica》2023年第11期2307-2321,共15页Bin Zhang Shao-han Xie Jun-yi Hu Si-jia Lei Liang-hua Shen Hong-tao Liu Qing Zheng Zhi-ming Zhang Chun-lian Wu Qiang Li Feng Wang; supported by the Guangzhou Basic and Applied Basic Research Project(to FW);Natural Science Foundation of Guangdong Province(NO.2022A1515012636);High-level University Construction Project and 2019 Ministry of Education“Chunhui Plan”Cooperative Scientific Research Project(NO.131).; Breast cancer is one of the most common malignant tumors with high mortality due to metastases. SCRIB, a scaffold protein mainly distributed in the cell membrane, is a potential tumor suppressor. Mislocalization and a...; 关键词：breast cancer scribble planar cell polarity protein(SCRIB) HnRNP A1 alternative splicing invasion ASO-SCRIB

Sonic hedgehog signaling:Alternative splicing and pathogenic role in medulloblastoma被引量：2: 《Genes & Diseases》2023年第5期2013-2028,共16页Meiyu Qu Qiangqiang He Jiahao Luo Tingyu Shen Ruibo Gao Yana Xu Chengyun Xu Muhammad Qasim Barkat Ling-Hui Zeng Ximei Wu; supported by the National Natural Science Foundation of China(No.31571493,81741043,31871395,82000046,and 32170841).; Alternative splicing(AS)produces the different mRNA splicing bodies,which are then translated into multiple protein isoforms and participate in various biological functions.With a deeper understanding of alternative s...; 关键词：Alternative splicing EXON Hedgehog signaling MEDULLOBLASTOMA Tumor suppressor

Association of Haplotypes in Exon 4 of KLK2 Gene with Raised Serum Prostate-Specific Antigen: 《American Journal of Molecular Biology》2023年第1期57-66,共10页Innocent S. I. Ogbu Ogochukwu A. Nwankwo Chinemere C. Ogbu Emmanuel Nna Kingsley K. Anya Malachy O. Odoh David C. Obasi; The standard diagnostic modalities for Prostate Cancer (PC) include serum Prostate-Specific Antigen (PSA) assay, Digital Rectal Examination (DRE), and histological examination of prostate biopsy. They are limited by l...; 关键词：Prostate Cancer Prostate-Specific Antigen Kallikrein 2 Gene Genetic Mutations Haplotypes Short Nucleotidepolymorphism

Identification of 1q21.1 microduplication in a family:A case report被引量：1: 《World Journal of Clinical Cases》2023年第4期874-882,共9页Ting-Ting Huang Hai-Feng Xu Shang-Yu Wang Wen-Xin Lin Yie-Hen Tung Kaleem Ullah Khan Hui-HuiZhang Hu Guo Guo Zheng Gang Zhang; BACKGROUND Copy number variation(CNV)has become widely recognized in recent years due to the extensive use of gene screening in developmental disorders and epilepsy research.1q21.1 microduplication syndrome is a rare ...; 关键词：1q21.1 microduplication syndrome EPILEPSY Copy number variation FAMILIAL Whole exon sequencing Congenital developmental disorders Case report

Efficacy of EGFR-TKI sequential therapy in patients with EGFR exon 19 insertion-positive non-small-cell lung cancer:A case report: 《World Journal of Clinical Cases》2022年第6期1883-1888,共6页Bin-Bin Shan Yuan Li Chang Zhao Xiao-Qin An Quan-Mao Zhang; BACKGROUND Insertions in exon 19 in the epidermal growth factor receptor gene(EGFR)is a rarely seen mutation in non-small cell lung cancer.These patients have been effectively treated with sequential EGFR tyrosine kin...; 关键词：Non-small cell lung cancer Next-generation sequencing EGFR exon 19 insertion AFATINIB Case report

A rare case of omental extra-gastrointestinal stromal tumor showing two coexisting mutations on exon 14 of the PDGFRA gene: 《Gastroenterology Report》2021年第4期377-379,I0003,共4页Gianluca Caruso Luca Pacini Angelo Iossa Claudio Di Cristofano Daniela Bastianelli Gianfranco Silecchia Maria Mele Vincenzo Petrozza Antonella Calogero Elena De Falco; Introduction Gastrointestinal stromal tumors(GISTs)are neoplasms arising from mesenchymal cells localized into the muscularis propria of the gastrointestinal(GI)tract[1];5%of GISTs are extra-GISTs(EGISTs),as they diff...; 关键词：胃肠道外间质瘤 neoplasms MUSCULAR

LncRNA AFAP1-AS1/miR-27b-3p/VEGF-C axis modulates stemness characteristics in cervical cancer cells被引量：6: 《Chinese Medical Journal》2021年第17期2091-2101,共11页Meng Xia Li-Jun Duan Bi-Nan Lu Yu-Zhou Pang Zong-Ran Pang; Background:Long non-coding RNA(lncRNA)actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)functions as a competing endogenous RNA to regulate target genes expression by sponging microRNAs(miRs)to play cancer...; 关键词：Hyaluronic acid receptor cluster of differentiation 44 variant exon 6 Cell stemness Cervical cancer Long non-coding RNA actin filament-associated protein 1 antisense RNA 1 MicroRNA-27b-3p

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