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Thailand and Thailand Science Research and Innovation Fund Chulalongkorn University,No.HEA663000047.
Functional constipation(FC)is considered the most common functional gastrointestinal disorder in children with a pooled global prevalence of 14.4%(95%confidence interval:11.2-17.6)when diagnosed based on the Rome IV c...
OBJECTIVE:To investigated the laxative,anti-diarrheal,hepatoprotective and diuretic activity of Sterculia diversifolia and its isolated compounds.METHODS:The laxative activity was studied by counting wet stools while ...
OBJECTIVE Senna and rhubarb are classified as stimulative laxatives,and known to have similar effective constituents,the anthraquinones.Being protected by theβ-glucoside bond,the anthraquinones can reach the intestin...
BACKGROUND Lactulose is approved for the symptomatic treatment of constipation,a gastrointestinal(GI)complication common in individuals with diabetes.Lactulose products contain carbohydrate impurities(e.g.,lactose,fru...
Supported by Xinglin Scholar,Xinglin Young Talent Program,No.RC-2017-02-07;Shanghai Three-year Action Plan for Accelerating the Development of Traditional Chinese Medicine,No.ZY(2018-2020)-CCCX-2002-01;and Research Fund of Longhua Hospital,No.2018YM05.
The incidence of cathartic colon has been increasing,but satisfactory treatments are still lacking.In order to study the pathological mechanisms of the disorder and identify effective treatment methods,researchers hav...
the National Natural Science Foundation of China(81673562 and 81973467);the Fundamental Research Funds for the Central Universities of China(2020-JYB-ZDGG-033).
Objective:To determine the mechanism of the laxative effect of rhubarb(Rheum tanguticum Maxim.ex Balf.)in rats using a combined bioinformatic and in vivo approach.Methods:Substances derived from rhubarb that are prese...
Supported by Project of National Natural Science Foundation(81360524&81660701);Natural Science Foundation Project of Guangxi(2016 GXNSFAA380148&2014GXNSFAA118208);Program of Key Laboratory for Purification and Quality Analysis of TCM Extraction in Guangxi Universities(Gui Jiao Ke Yan[2014]No.6);Program of Scientific Research Third-level Laboratory "Chinese(Zhuang) Medicine Chemical and Quality Analysis Laboratory" of State Administration of Traditional Chinese Medicine(Guo Zhong Yi Yao Fa 2009[No.21])
[Objectives] To study the differences in the effects of Rheum officinale and wine prepared Rheum palmatum Dachengqi Decoction(DCQ) on laxative effect of mice.[Methods]First,72 mice were randomly divided into positive ...
Background: Quality of life (QoL) is impaired in chronic constipation. Among nonprescription laxatives QoL data out of randomized controlled trials are available only for bisacodyl and sodium picosulfate (SPS). Method...
Constipation is a condition in which a person or animal has difficulty in eliminating solid waste from the body and the faeces are hard and dry. It is mainly characterized by a difficulty in defecation. The aim of the...
fundedby Merck & Co., Inc., Kenilworth, NJ, United States
AIM:to evaluate the efficacy and safety of polyethylene glycol(PEG)3350 in subjects with self-reported occasional constipation.METHODS:Eligible subjects≥17 years of age were randomized to receive either placebo or PE...