Supported by Natural Science Fund of Heilongjiang Province(C201424)
The pharmacokinetics of milbemycin oxime was investigated in dogs following oral(per os, PO) and intravenous(IV) administration. Three groups of dogs received milbemycin oxime tablets as a single PO dose equal to 0.25...
This work is supported by the National Natural Science Foundation of China (grant No: 20372056);a Research Fund from the Royal Society of Chemistry. UK.
A novel macrolactonization method was developed using a chiral β-lactam as the template. This novel method features that the macrocyclization is simultaneously achieved while a TBS protected hydroxy group is deprotec...