supported by the National Natural Science Foundation of China(32270442,31872219,31370401,32030011,31630071,31772448);National Key Research and Development Program of China(2022YFF1301602);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_1747,KYCX23_1740)。
High-altitude and marine mammals inhabit distinct ecosystems but share a common challenge:hypoxia.To survive in low-oxygen environments,these species have evolved similar phenotypic pulmonary adaptations,characterized...
supported by the National Natural Science Foundation of China(32330015,31821001);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB31000000)。
DNA methylation plays a crucial role in environmental adaptations.Here,using whole-genome bisulfite sequencing,we generated comprehensive genome-wide DNA methylation profiles for the high-altitude Yunnan snub-nosed mo...
supported by the Key Research and Development Projects in Tibet:Preservation of Characteristic Biological Germplasm Resources and Utilization of Gene Technology in Tibet(XZ202001ZY0016N);National Natural Science Foundation of China(32072980);Special Finance of Tibet Autonomous Region(XZNKY-2019-C-053)。
Persistent uplift means the Qinghai-Tibet Plateau(QTP)is an ideal natural laboratory to investigate genome evolution and adaptation within highland environments.However,how paleogeographic and paleoclimatic events inf...
supported by the National Natural Science Foundation of China (31621062);Strategic Priority Research Program of the Chinese Academy of Sciences (XDA2004010302);Second Tibetan Plateau Scientific Expedition and Research (STEP)Program (2019QZKK05010703);supported by the National Natural Science Foundation of China (91731304, 31822048);Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13020600);Qinghai Department of Science and Technology Major Project;State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan University(2018KF001)supported by the Animal Branch of the Germplasm Bank of Wild Species,Chinese Academy of Sciences (Large Research Infrastructure Funding)
Over the last several hundred years,donkeys have adapted to high-altitude conditions on the Tibetan Plateau.Interestingly,the kiang,a closely related equid species,also inhabits this region.Previous reports have demon...
supported by the Animal Branch of the Germplasm Bank of Wild Species of the Chinese Academy of Sciences(Large Research Infrastructure Funding)
A new species of the genus Amolops Cope, 1865 is described from Xinduqiao, Kangding, Sichuan. It was previously identified as Amolops kangtingensis, which is synonymized to Amolops mantzorum in this study. The new spe...
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13010000);the National Natural Science Foundation of China(91631306 to BS,31671329 to XQ,31460287 to Ou.,31501013 to HZ and 31360032 to CC);the National 973 program(2012CB518202 to TW);the State Key Laboratory of Genetic Resources and Evolution(GREKF15-05,GREKF16-04);the Zhufeng Scholar Program of Tibetan University
Tibetans are welt adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few have been studied. Here we report on a hypoxia gene (GCH1, GTP-cyc...
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13010000);the National Natural Science Foundation of China(91631306 to BS,31671329 to XQ,31460287 to Ou,31501013 to HZ,and 31360032 to CC);the National 973 program(2012CB518202 to TW);the State Key Laboratory of Genetic Resources and Evolution(GREKF15-05,GREKF16-04);the Zhufeng Scholar Program of Tibetan University
The genetic adaptation of Tibetans to high altitude hypoxia likely involves a group of genes in the hypoxic pathway, as suggested by earlier studies. To test the adaptive role of the previously reported candidate gene...