COTRANSPORTER

作品数：54被引量：110H指数：6
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相关领域：医药卫生更多>>
相关作者：孙怀宇更多>>
相关机构：中国医科大学首都医科大学更多>>
相关期刊：《Chinese Medical Journal》《World Journal of Cardiology》《World Journal of Diabetes》《Animal Husbandry and Feed Science》更多>>
相关基金：国家自然科学基金广东省自然科学基金美国中华医学基金会项目北京市自然科学基金更多>>
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Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes
《World Journal of Diabetes》2025年第4期19-24,共6页Meng Gao Meng-Ting Dai Guo-Hua Gong 
Supported by The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008;The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138;The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003。
In this editorial,we discussed the article published in the recent issue of the World Journal of Diabetes.To understand the effect of mizagliflozin on kidney injury induced by diabetes,we focused on the mechanisms by ...
关键词：Glucose metabolism Sodium-D-glucose cotransporter 1 Glucose reabsorption Mitochondrial dysfunction Reactive oxygen species Inflammation 
Sodium glucose cotransporter 2 inhibitors in the management of heart failure:Veni,Vidi,and Vici
《World Journal of Cardiology》2024年第10期550-563,共14页Monika Bhandari Akshyaya Pradhan Pravesh Vishwakarma Abhishek Singh Rishi Sethi 
Heart failure(HF)is a chronic disease associated with high morbidity and mortality rates.Renin-angiotensin-aldosterone system blockers(including angiotensin receptor/neprilysin inhibitors),beta-blockers,and mineraloco...
关键词：Heart failure with preserved ejection fraction Gliflozins DIURESIS NATRIURESIS N terminal-pro brain natriuretic peptide Heart failure hospitalization 
Sodium-Glucose Cotransporter 2 Inhibitors in Adult and Pediatric Congenital Heart Disease: Review of Emerging Data and Future Directions
《Congenital Heart Disease》2024年第4期419-433,共15页William H.Marshall V Lydia K.Wright 
Heart failure(HF)is common in patients with congenital heart disease(CHD)and there are limited medical therapies.Sodium-glucose cotransporter 2 inhibitors(SGLT2i)are a proven medical therapy in patients with acquired ...
关键词：Congenital heart disease heart failure sodium-glucose 2 cotransporter inhibitors systemic right ventricle FONTAN 
Sodium glucose cotransporter-2 inhibitors and heart disease:Current perspectives
《World Journal of Cardiology》2024年第5期240-259,共20页Sunetra Mondal Subhodip Pramanik Vibhu Ranjan Khare Cornelius James Fernandez Joseph M Pappachan 
Sodium glucose cotransporter-2 inhibitors(SGLT-2i)are antidiabetic medications with remarkable cardiovascular(CV)benefits proven by multiple randomised controlled trials and real-world data.These drugs are also useful...
关键词：SGLT2 inhibitors SGLT2i Cardiovascular disease Heart failure Atherosclerotic cardiovascular disease Diabetic kidney disease 
Metabolic disorders in prediabetes:From mechanisms to therapeutic management被引量：1
《World Journal of Diabetes》2024年第3期361-377,共17页Wen-Xin Ping Shan Hu Jing-Qian Su Song-Ying Ouyang 
Supported by National Natural Science Foundation of China,No.31770948,No.31570875,and No.81803547;Natural Science Foundation of Fujian Province,No.2021J01204;and Fujian Provincial Regional Development Project,No.2021N3005.
Diabetes,one of the world's top ten diseases,is known for its high mortality and complication rates and low cure rate.Prediabetes precedes the onset of diabetes,during which effective treatment can reduce diabetes ris...
关键词：PREDIABETES Glucagon-like peptide agonists Sodium–glucose cotransporter 2 inhibitors Vitamin D Chinese herbal medicines 
Comparative efficacy of sodium glucose cotransporter-2 inhibitors in the management of type 2 diabetes mellitus:A real-world experience被引量：2
《World Journal of Diabetes》2024年第3期463-474,共12页Lubna Islam Dhanya Jose Mohammed Alkhalifah Dania Blaibel Vishnu Chandrabalan Joseph M Pappachan 
BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT-2i)are a class of drugs with modest antidiabetic efficacy,weight loss effect,and cardiovascular benefits as proven by multiple randomised controlled trials(RCT...
关键词：Sodium glucose cotransporter-2 inhibitors Empagliflozin Canagliflozin DAPAGLIFLOZIN Type 2 diabetes mellitus Cardiovascular disease Albumin creatinine ratio DIABESITY 
Neuronal K^(+)-Cl^(-) cotransporter KCC2 as a promising drug target for epilepsy treatment被引量：2
《Acta Pharmacologica Sinica》2024年第1期1-22,共22页Erin McMoneagle Jin Zhou Shiyao Zhang Weixue Huang Sunday Solomon Josiah Ke Ding Yun Wang Jinwei Zhang 
the financial support from the National Natural Science Foundation of China(Grant Nos.:82170406,81970238,and 32111530119);Shanghai Municipal Science and Technology Major Project(Grant No.:2018SHZDZX01);The Royal Society UK(Grant No.:IECINSFC/201094);The Commonwealth Scholarship Commission UK(Grant No.:NGCA-2020-43)。
Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures.y-Aminobutyric acid(GABA)serves as the primary fast inhibitory neurotransmitter in the brain,and GABA binding to the GABAA receptor(GA...
关键词：EPILEPSY GABAergic inhibition K+-Cl-cotransporter KCC2 chloride homeostasis signaling regulatory pathways small molecularcompounds 
The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies被引量：1
《Journal of Pharmaceutical Analysis》2023年第12期1471-1495,共25页Shiyao Zhang Nur Farah Meor Azlan Sunday Solomon Josiah Jing Zhou Xiaoxia Zhou Lingjun Jie Yanhui Zhang Cuilian Dai Dong Liang Peifeng Li Zhengqiu Li Zhen Wang Yun Wang Ke Ding Yan Wang Jinwei Zhang 
We are very grateful for the financial support from the National Natural Science Foundation of China(Grant Nos.:82170406,81970238,and 32111530119);Shanghai Municipal Science and Technology Major Project,China(Grant No.:2018SHZDZX01);The Royal Society UK(Grant No.:IEC\NSFC\201094);the Commonwealth Scholarship Commission UK(Grant No.:NGCA-2020-43).
The solute carrier family 12(SLC12)of cation-chloride cotransporters(CCCs)comprises potassium chloride cotransporters(KCCs,e.g.KCC1,KCC2,KCC3,and KCC4)-mediated Cl^(-)extrusion,and sodium potassium chloride cotranspor...
关键词：Cation-chloride cotransporters Chloride volume regulation Cotransporter assays Drug discovery 
Heterogeneity in cardiorenal protection by Sodium glucose cotransporter 2 inhibitors in heart failure across the ejection fraction strata:Systematic review and meta-analysis
《World Journal of Nephrology》2023年第5期182-200,共19页Saeed Taheri 
BACKGROUND Gliflozins or Sodium glucose cotransporter 2 inhibitors(SGLT2i)are relatively novel antidiabetic medications that have recently been shown to represent favorable effects on patients’cardiorenal outcomes.Ho...
关键词：Sodium glucose cotransporter 2 inhibitors Cardiovascular Renal outcome efficacy Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction 
Waggle needling Yanglingquan(GB34) enhances cerebral blood flow and ameliorates condition of spastic paresis in rats with middle cerebral artery occlusion induced by surgical nylon suture
《Journal of Traditional Chinese Medicine》2023年第3期514-522,共9页ZHANG Zhou MU Jiedan MA Liangxiao YU Wenyan SUN Tianyi QIAN Xu TIAN Yuan ZHANG Yidan WANG Junxiang 
Supported by Scientific Research Development Fund Program of National Natural Science Foundation of China:Study on the Mechanism of Waggle Needling GB34 Relieving Spasticity in Poststroke Rats Based on KCC2-GABAA Receptor Pathway(No.81774417);the Fundamental Research Funds for the Central Universities of China:Research and Development of Physical Therapy Technology and Equipment for Regulation of Human Functional State(No.2020-JYB-ZDGG-062)。
OBJECTIVE:To evaluate the therapeutic efficacy and the influence on cerebral blood supply of waggle needling Yanglingquan(GB34) on spastic paresis(SP) rats after middle cerebral artery occlusion(MCAO) induced and inve...
关键词：spastic paresis acupuncture cerebrovascular circulation laser speckle imaging γ2 subunit of theγ-aminobutyric acid receptor A K+-Cl-cotransporter 2 
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