supported by the National Natural Science Foundation of China,No.82201582(to QT);Scientific and Technological Research Program of Chongqing Municipal Education Commission,No.KJQN202200457(to QT);General Project of Changqing Natural Science Foundation,No.cstc2021jcyjmsxmX0442(to ZL);CQMU Program for Youth Innovation in Future Medicine,No.W0044(to ZD and GH);Direct Research Project for PhD of Chongqing,No.CSTB2022BSXM-JCX0051(to ZL);the Project of the Top-Notch Talent Cultivation Program For the Graduate Students of Chongqing Medical University,No.BJRC202310(to CG)。
Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque formation.Therefore,resto ring normal lysosomal funct...
Kinetics of the gas-phase reactions of•OH radicals with a series of fluoroesters were studied for the first time at 298±3 K and atmospheric pressure.Relative rate coefficients were determined by in situ FTIR spectros...
supported by the Ministry of Science and Higher Education of the Russian Federation in the Framework of State Assignment of PSCBR RAS 075-00609-24-01(No.1022080100047-5-1.6.4,Neuroprotective drugs of a new generation).
Objective:Activation of mitophagy is a promising option to overcome the mitochondrial malfunction that accompanies many diseases.Herein,we investigate the mechanisms underlying the ability of sodium lactate and pyruva...
supported by the Natural Science Foundation of Shanghai,No.22ZR147750;Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission,No.23Y11906600;Shanghai Changzheng Hospital Innovative Clinical Research Project,No.2020YLCYJ-Y02(all to YY).
Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within...
Under the auspices of National Natural Science Foundation of China(No.41929002);Science and Technology Department of Sichuan Province(No.2021YFS0338)。
Enhanced sulfur and nitrogen deposition has been observed in many transect regions worldwide,from urban/agricultural areas to mountains.The Sichuan Basin(SCB),with 18 prefectural cities,is the most economically-develo...
supported by the Fundamental Research Funds for the Central Universities of China(No.B220202066);the Natural Science Foundation of Jiangsu Province(No.BK20200527);the Anhui Provincial Key Laboratory of Environmental Pollution Control and Resource Reuse(No.2021EPC05).
Anaerobic digestion has been defined as a competitive approach to facilitate the recycling of corn stalks.However,few studies have focused on the role of direct interspecies electron transfer(DIET)pathway in the acidi...
supported by the National Natural Science Foundation of China(No.U19A2046)。
The types and contents of phyllosilicate minerals in soils play an important role in soil acidification,as soil acid buffering capacity varies with the composition of the phyllosilicate minerals.In addition to aluminu...
This study aims to evaluate the development of soil reaction values in 15 key localities of soil Partial Monitoring System from 1994 to 2023, and to identify the most important regional drivers of pH value development...
supported by a Lee Kong Chian School of Medicine Dean’s Postdoctoral Fellowship(021207-00001)from Nanyang Technological University Singapore;a Mistletoe Research Fellowship(022522-00001)from the Momental Foundation USA(to CHL).
Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellu...
Over recent decades, Gampaha district, Sri Lanka, has experienced significant urbanisation and industrial growth, increasing groundwater demand due to limited and polluted surface water resources. In 2013, a community...