POLYCYCLIC

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Hymoins A–C,three unusual polycyclic polyprenylated acylphloroglucinols with lipid-lowering activity from Hypericum monogynum
《Chinese Chemical Letters》2025年第3期411-414,共4页Chunmao Yuan Yanrong Zeng Lei Huang Yu Mou Jun Jin Ping Yi Yanmei Li Xiaojiang Hao 
financially supported by the National Natural Science Foundation of China(Nos.32270413,82060631,82160808,and 82360035);the Science and Technology Department of Guizhou Province(Nos.QKHJC 2020–1Z076,QKHJC-ZK[2023]YB156,QKHJC-ZK[2021]YB569,and QKHPTRC[2020]5008);Excellent Young Talents Plan of Guizhou Medical University(2023,No.106);the 13thbatch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633);Guizhou Science and Technology Innovation Talent Team(No.QKHPTRC–CXTD[2022]007);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);the project of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(Nos.FAMP202102K and QJJ[2023]113)。
Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin...
关键词：Hypericum monogynum Polycyclic polyprenylated ACYLPHLOROGLUCINOLS Structure elucidation Lipid-lowering activity Mechanistic study 
Spirohypertones A and B as potent antipsoriatics:Tumor necrosis factor-αinhibitors with unprecedented chemical architectures
《Acta Pharmaceutica Sinica B》2024年第6期2646-2656,共11页Yulin Duan Weiguang Sun Yongqi Li Zhengyi Shi Lanqin Li Yeting Zhang Kun Huang Zhiping Zhang Changxing Qi Yonghui Zhang 
supported by the Program for Changjiang Scholars of Ministry of Education of the People's Republic of China(T2016088);the National Natural Science Foundation for Distinguished Young Scholars(81725021,China)the National Natural Science Foundation of China(Nos.82003633,32100321 and 32300335);the National Natural Science Foundation of Hubei Province(2023AFB791 and 2023AFB530,China);Knowledge Innovation Project of Wuhan Science and Technology Bureau(2023020201020534,China);the Research and Development Program of Hubei Province(2020BCA058,China);the Open Foundation of Hubei Key Laboratory of Wudang Local Chinese Medicine Research(WDCM2023010,China);Funded by Open Research Fund Program of State Key Laboratory of Biocatalysis and Enzyme Engineering(SKLBEE2023003,China).
Tumor necrosis factor-α(TNF-α)is a promising target for inflammatory and autoimmune diseases.Spirohypertones A(1)and B(2),two unprecedented polycyclic polyprenylated acylphloroglucinols with highly rearranged skelet...
关键词：Hypericum patulum Polycyclic polyprenylated acylphloroglucinols Tumor necrosis factor-αinhibitory activity PSORIASIS 
Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum
《Chinese Journal of Natural Medicines》2024年第3期273-279,共7页DUAN Yulin SHI Zhengyi SONG Fei HOU Zhangrong TAN Xiaosheng ZHANG Yeting HAO Xincai CHEN Gang QI Changxing ZHANG Yonghui 
supported by the Program for Changjiang Scholars of Ministry of Education of the People’s Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Science and Technology Project of China(No.2018ZX09201001-001-003);the National Natural Science Foundation of China(Nos.82003633,32100321,and 32300335);the Research and Development Program of Hubei Province(No.2020BCA058);the Open Foundation of Hubei Key Laboratory of Wudang Local Chinese Medicine Research(No.WDCM2022003);the National Natural Science Foundation of Hubei Province(No.2023AFB530);the Knowledge Innovation Project of Wuhan Science and Technology Bureau(No.2023020201020534).
Hyparillums A(1)and B(2),two previously unidentified polycyclic polyprenylated acylphloroglucinols(PPAPs)with intricate architectures,were isolated from Hypericum patulum Thunb.Hyparillum A was the first PPAP with eig...
关键词：Polycyclic polyprenylated acylphloroglucinols Hypericum patulum Thunb. Immunosuppressive activities Structure elucidation. 
Hyperbenzones A and B,two 1,2-seco and rearranged polycyclic polyprenylated acylphloroglucinols from Hypericum beanii被引量：1
《Chinese Chemical Letters》2022年第8期4121-4125,共5页Weijia Lu Yanqiu Zhang Yawei Li Shengtao Ye Jun Luo Lingyi Kong Wenjun Xu 
supported by the National Natural Science Foundation of China(Nos.31900287 and 81773886);the 111 Project from Ministry of Education of China and the State Administration of Foreign Export Affairs of China(No.B18056);Special fund from the Central Committee for guiding local scientific and technological development of Shenzhen(No.2021Szvup161)。
Two novel seco-polycyclic polyprenylated acylphloroglucinols(PPAPs),hyperbenzones A(1)and B(2),were isolated from the roots of Hypericum beanii,together with one known biosynthetic congener 3.Compound 1 incorporates a...
关键词：seco-PPAPs Hypericum beanii Hyperbenzones A and B NASH 1 2-seco-Bicyclic derivatives 
Hybeanones A and B,Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii
《Chinese Journal of Chemistry》2022年第1期53-58,共6页Beiye Yang Changxing Qi Zeyu Yao Shuang Lin Fengli Li Weiguang Sun Zhengxi Hu Yonghui Zhang 
financially supported by the National Natural Science Foundation for Distinguished Young Scholars(81725021);the National Science and Technology Project of China(2018ZX09201001-001-003);the Innovative Research Groups of the National Natural Science Foundation of China(81721005);the National Natural Science Foundation of China(82003633);the Academic Frontier Youth Team of HUST(2017QYTD19);the Fundamental Research Funds for the Central Universities(2020kfyXJJS083);the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST).
Hybeanones A and B(1 and 2),two highly oxygenated and rearranged polycyclic polyprenylated acylphloroglucinols(PPAPs),were isolated from the aerial parts of Hypericum beanii.Their structures comprising absolute config...
关键词：Hypericum beanii Natural products Structure elucidation INHIBITORS Molecular docking 
Type B polycyclic polyprenylated acylphloroglucinols from the roots of Hypericum beanii被引量：3
《Chinese Journal of Natural Medicines》2021年第5期385-390,共6页LI Wei-Xian XU Wen-Jun LUO Jun YANG Lei KONG Ling-Yi 
the National Natural Science Foundation of China(No.31900287);the Drug Innovation Major Project(2018ZX09711-001-007);the China Postdoctoral Science Foundation(2017M621889)。
Two new type B polycyclic polyprenylated acylphloroglucinols(PPAPs)(1 and 2)and a known biogenetic precursor hyperbeanol Q(3)were isolated from the root extract of Hypericum beanii,a medicinal plant widespread in sout...
关键词：Polyprenylated acylphloroglucinol Hypericum beanii Hyperbeone A ECD 
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