GERM-LINE

作品数：6被引量：16H指数：2
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相关期刊：《Science China(Life Sciences)》《Journal of Genetics and Genomics》《Protein & Cell》《World Journal of Gastrointestinal Oncology》更多>>
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Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene被引量：4
《Science China(Life Sciences)》2017年第2期152-157,共6页Yuting Chen Wenqing Lu Na Gao Yi Long Yanjiao Shao Meizhen Liu Huaqing Chen Shixin Ye Xueyun Ma Mingyao Liu Dali Li 
supported by the State Key Development Programs of China (2012CB910400 to Mingyao Liu);the National Natural Science Foundation of China (31371455, 31171318 and 81330049);the Science and Technology Commission of Shanghai Municipality (14140900300)
The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases(TALENs) technol...
关键词：TALENs Lepr knockout rat germ-line transmission 
Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos被引量：1
《Protein & Cell》2015年第7期472-475,共4页Si Wang Fei Yi Jing Qu 
Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused wi...
Epigenetic reduction of DNA repair in progression to gastrointestinal cancer被引量：2
《World Journal of Gastrointestinal Oncology》2015年第5期30-46,共17页Carol Bernstein Harris Bernstein 
Deficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased risk of gastrointestinal(GI) cancer. In sporadic GI cancers, mutations in DNA repair genes are relatively rare. Howev...
关键词：EPIGENETIC DNA damage DNA REPAIR DNA REPAIR deficiency DISORDERS Epimutation Genomicinstability GERM-LINE mutation MicroRNAs Precancerousconditions GASTROINTESTINAL cancer 
RNA Guided Genome Editing in Mouse Germ-Line Stem Cells被引量：1
《Journal of Genetics and Genomics》2014年第7期409-411,共3页Xuepeng Wang Yan Yuan Quan Zhou Haifeng Wan Mei Wang Qi Zhou Xiao-Yang Zhao Jiahao Sha 
supported by the National Basic Research Program of China(No.2013CB947903);the National Natural Science Foundation Project Outstanding Young Scholars(No.31322036)
Spermatogonial stem cells （SSCs） reside on the basement membrane of the seminiferous tubules in mammalian testes （Nagano et al., 1998）. After isolation and purification of SSCs from mouse testis, SSCs can be cultu...
关键词：EGFP In 
Cloning,characterization,and expression analysis of the DEAD-box family genes,Fc-vasa and Fc-PL10a,in Chinese shrimp (Fenneropenaeus chinensis)被引量：8
《Chinese Journal of Oceanology and Limnology》2010年第1期37-45,共9页周倩如 邵明瑜 秦贞奎 康庆浩 张志峰 
Supported by the Specialized Research Fund for the Doctoral Program of Higher Education,China (No. 200804230015);the National High Technology Research and Development Program of China (863 Program) (No. 2006AA10A401)
RNA helicases of the DEAD-box and related families are involved in various cellular processes including DNA replication, DNA repair, and RNA processing. However, the function of DEAD-box proteins in aquaculture specie...
关键词：DEAD-BOX Fenneropenaeus chinensis GERM-LINE VASA PL10 
Establishment of Germ-line Competent C57BL/6J Embryonic Stem Cell Lines
《Journal of Reproduction and Contraception》2004年第4期201-208,共8页Gui-jun YAN Zheng GU Jian WANG Jia-ke TSO 
Objective To establish C57BL/6J embryonic stem （ES） cell lines with potential germ- line contribution Methods ES cells were isolated from blastocyst inner cell mass of C5 7BL/6J mice, and cultured for 15 passages, a...
关键词：C57BL/6J mice embryonic stem （ES） cell ICR mice blastocysts germ-line competent 
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