The axon initial segment(AIS)region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels(Nav).Nav channels comprise several serine residues responsib...
the National Nature Science foundation(81000554);Guangdong Nature Science foundation(2018A030313345);the Science and Technology Foundation of Guangdong Province(2008B030301058).
Background:Voltage-gated sodium channels are the targets of many commonly used antiepileptic drugs.NaV1.6,encoded by Scn8a,increased in chronic mesial temporal epilepsy animal models and co-localized with Ankyrin-G,en...