URACIL

作品数：57被引量：87H指数：5
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相关领域：医药卫生更多>>
相关作者：李平王孝伟王卫华刘俊义张冬英更多>>
相关机构：北京大学中国海洋大学曲阜师范大学云南农业大学更多>>
相关期刊：《Chemical Research in Chinese Universities》《Chinese Journal of Polymer Science》《Chinese Journal of Structural Chemistry》《Open Journal of Medicinal Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家高技术研究发展计划更多>>
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A novel CRISPR/Cas9 system with high genomic editing efficiency and recyclable auxotrophic selective marker for multiple-step metabolic rewriting in Pichia pastoris被引量：2
《Synthetic and Systems Biotechnology》2023年第3期445-451,共7页Xiang Wang Yi Li Zhehao Jin Xiangjian Liu Xiang Gao Shuyuan Guo Tao Yu 
Key-Area Research and Development Program of Guangdong Province(2022B1111080005);the National Key Research and Development Program of China(2020YFA0907800 and 2021YFA0911000);the National Natural Science Foundation of China(NSFC 32071416);the Shenzhen Institute of Synthetic Biology Scientific Research Program(Grant No.JCHZ20200003);Shenzhen Key Laboratory for the Intelligent Microbial Manufacturing of Medicines(ZDSYS20210623091810032);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000);the China Postdoctoral Science Foundation(2020M682973);Guangdong Basic and Applied Basic Research Foundation(2020A1515110927).
The methylotrophic budding yeast Pichia pastoris has been utilized to the production of a variety of heterologous recombinant proteins owing to the strong inducible alcohol oxidase promoter(pAOX1).However,it is diffic...
关键词：Pichia pastoris Uracil auxotroph CRISPR/Cas9 Recyclable selective marker Homology directed repair 
Identification of the Decay Pathway of Photoexcited Nucleobases被引量：1
《Ultrafast Science》2023年第2期31-38,共8页Xiangxu Mu Ming Zhang Jiechao Feng Hanwei Yang Nikita Medvedev Xinyang Liu Leyi Yang Zhenxiang Wu Haitan Xu Zheng Li 
supported by the National Natural Science Foundation of China[grant numbers 12174009,11974031,12104082,12234002,and 92250303];Beijing Natural Science Foundation[grant number Z220008];N.M.gratefully acknowledges financial support from the Czech Ministry of Education,Youth,and Sports[grantnumbers LTT17015,LM2018114,and EF16_013/0001552].
The identification of the decay pathway of the nucleobase uracil after being photoexcited by ultraviolet light has been a long-standing problem.Various theoretical models have been proposed but yet to be verified.Here...
关键词：methods EXCITED URACIL 
Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation被引量：2
《Acta Pharmacologica Sinica》2021年第3期460-469,共10页Yu-hang Zhang Shu-xiang Cui Sheng-biao Wan Shu-hua Wu Xian-jun Qu 
supported by the National Natural Science Foundation of China(91629303/81673449/81872884/81973350);the Beijing Natural Science Foundation and Scientific Research Program of Municipal Commission of Education(KZ201710025020/KZ201810025033)。
Sphingosine-1-phosphate(S1P),the backbone of most sphingolipids,activating S1P receptors(S1PRs)and the downstream G protein signaling has been implicated in chemoresistance.In this study we investigated the role of S1...
关键词：colorectal cancer 5-FU resistance sphingosine-1-phosphate(SI P) S1PR2 internalization endoplasmic reticulum calcium([Ca^(2+)]ER) uracil generation JTE-013 
Improving the Cpf1-mediated base editing system by combining dCas9/dead sgRNA with human APOBEC3A variants
《Journal of Genetics and Genomics》2021年第1期92-95,共4页Meng Lian Fangbing Chen Xingyun Huang Xiaozhu Zhao Shixue Gou Nan Li Qin Jin Hui Shi Yanhui Liang Jingke Xie Weikai Ge Zhenpeng Zhuang Jiaowei Wang Yinghua Ye Yi Yang Kepin Wang Liangxue Lai Han Wu 
supported by the National Natural Science Foundation of China (31901048);the National Key Research and Development Program of China (2017YFA0105103, 2019YFA0111500);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030503);Key Research & Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (2018GZR110104004);the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2019347);Science and Technology Planning Project of Guangdong Province, China (2019A1515012090, 2017B020231001, 2017B030314056, 2014B020225003);Science and Technology Program of Guangzhou, China (201704030034, 202007030003, 202002030382);Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019-I2M-5-025)。
Base editor-mediated C-to-T base conversion obviates the requirements of double-strand breaks,thereby showing promise as a tool for disease modeling and gene therapy(Gaudelli et al.,2017;Rees and Liu 2018).The most ac...
关键词：BASE URACIL thereby 
Antarctic thermolabile uracil-DNA-glycosylase- supplemented multiple cross displacement amplification using a label-based nanoparticle lateral flow biosensor for the simultaneous detection of nucleic acid sequences and elimination of carryover contamination被引量：1
《Nano Research》2018年第5期2632-2647,共16页Yi Wang Hui Li Yan Wang Huaqing Xu Jianguo Xu Changyun Ye 
Here, we report a novel and universal methodology,termed ＂ntarctic thermolabile uracil-DNA-glycosylase （AUDG）-supplemented nucleic acid amplification techniques （NAAs） using a labeled-based nanoparticle lateral f...
关键词：Antarctic thermolabile uracil-DNA-glycosylase（AUDG） nucleic acid amplification techniques （NAAs） multiple cross displacement amplification （MCDA） lateral flow biosensor （LFB） limit of detection （LOD） human papillomaviruses（HPV） 
Computational Studies on the Ground State Tautomer,Hydrogen Conformations and Vibrational Spectroscopic Analysis of Antitumor Agents:3-Deazauracil and 6-Azauracil被引量：1
《光谱学与光谱分析》2018年第4期1276-1282,共7页Cagri Cirak Nurettin Korozlu Yusuf Sert Fatih Ucun 
supported by Research Fund of the Erzincan University(Project no:FEN-A-150615-0149)
The ground state hydrogen conformations and vibrational analysis of 3-deazauracil(3DAU)and 6-azauracil(6AU)tautomers(4-enol and 2,4-diol forms)have been calculated using ab initio Hartree-Fock(HF)and density functiona...
关键词：3-Deazauracil 6-Azauracil TAUTOMERISM Conformation VIBRATIONAL spectra 
Benign perfluoroalkylation of uracils and uracil nucleosides via visible light-induced photoredox catalysis
《Chinese Chemical Letters》2017年第8期1751-1754,共4页Ben-Hou Zhang Jing-Jing Kong Yang Huang Yue-Guang Lou Xiao-Fei Li Chun-Yang He 
financially supported by the Young Talents Cultivation Program of the China Association for Science and Technology(No.2015-41);The Training Programme Foundation for the Talents of the Zun Yi Science and Technology Bureau(No.201540);Key Programs of Guizhou Province(125 Program,No.2015039);The Natural Science Foundation of Jiangsu Province(No.BK20141265)
In this work, an efficient and facile method for the preparation of 5-perfluoroalkylation uracils and uracil nucleosides through visible-light-mediated reaction has been developed. The reaction processes in high effic...
关键词：Uracils Uracil Nucleosides Blue LED Photoredox catalysis Perfluoroalkylation 
Tegafur-uracil-induced rapid development of advanced hepatic fibrosis被引量：1
《World Journal of Gastroenterology》2017年第31期5823-5828,共6页shuya honda koji sawada takumu hasebe shunsuke nakajima mikihiro fujiya toshikatsu okumura 
Tegafur-uracil has been reported to have only minor adverse effects and is associated with liver injury in 1.79% of Japanese patients. The development of tegafur-uracil-induced hepatic fibrosis with portal hypertensio...
关键词：Tegafur-uracil Drug-induced liver injury Hepatic fibrosis Portal hypertension Non-invasive assessment 
Dimeric structure of the uracil：proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters被引量：1
《Cell Research》2017年第8期1020-1033,共14页Xinzhe Yu Guanghui Yang Chuangye Yan Javier L Baylon Jing Jiang He Fan Guifeng Lu Kazuya Hasegawa Hideo Okumura Tingliang Wang Emad Tajkhorshid Shuo Li Nieng Yan 
Acknowledgments We thank J He, L Tang, F Yu, and S Huang at Shanghai Syn- chrotron Radiation Facility （SSRF）. This work was supported by funds from the Ministry of Science and Technology of China （2015CB910101, 2016YFA0500402, 2014ZX09507003-006） and the National Natural Science Foundation of China （31621092, 31630017, and 31611 130036）. The research of Nieng Yan was supported in part by an endowed professorship from Bayer Healthcare.
The Escherichia coli uracil：proton symporter UraA is a prototypical member of the nucleobase/ascorbate transporter （NAT） or nucleobase/cation symporter 2 （NCS2） family, which corresponds to the human solute carri...
关键词：uracil/proton symporter alternating access conformational change 
Treatment of perianal infection in acute leukemia hematopoietic stem celltransplantation with Xiongzhen ointment mixed with furacilin powder
《TMR Integrative Nursing》2017年第2期45-49,共5页Yang Song 
Objective： To investigate the effect of Xiongzhen ointment mixed with furaicillin powder on perianal care of patientswith acute myeloid leukemia M2a hematopoietic stem cell transplantation.Methods： A case of acute m...
关键词：Hematopoietic stem cell transplantation Xiongzhen ointment Furanicillin powder Laminar flow chamber Perianal care 
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