This work was supported by the National Natural Science Foundation of China(21975280);Shenzhen Science and Technology Research Funding(JCYJ20180507182530279);the Frontier Science Key Programs of Chinese Academy of Sciences(QYZDB-SSWSLH034),Guangdong Special Support Program(2017TX04C096);the Leading Talents of Guangdong Province Program(00201520);the City University of Hong Kong Strategic Research Grants(SRG,7005105 and 7005264).
Fluorescent probes with high signal/background ratio are needed for hybridization assays. Hence, the chromophore of green fluorescent protein (GFP), 4-hydroxybenzylidene-imidazolinone (HBI), was targeted as a potentia...
As DNA cleavage agent, a new diiron(Ⅲ) complex (Fe2Lb), in which a DNA-intercalator (pyrene) is covalently linked to a diferric moiety, has been synthesized and characterized. The DNA-binding property and DNA c...