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作品数：134被引量：230H指数：7
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相关作者：程远国岳建民孙汉董赵勤实林中文更多>>
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Hydroxyethyl starch conjugates co-assembled nanoparticles promote photodynamic therapy and antitumor immunity by inhibiting antioxidant systems
《Asian Journal of Pharmaceutical Sciences》2024年第5期166-181,共16页Xiang Chen Zhengtao Yong Yuxuan Xiong Hai Yang Chen Xu Xing Wang Qingyuan Deng Jiayuan Li Xiangliang Yang Zifu Li 
This work was financially supported by grants from the National Research and Development Program of China(2020YFA0211200,2020YFA0710700);the National Science Foundation of China(82172757);the Program for HUST Academic Frontier Youth Team(2018QYTD01);the HCP Program for HUST;the Opening fund of Hubei Key Laboratory of Bioinorganic Chemistry&Materia Medica(No.BCMM202302).
Photodynamic therapy(PDT)can produce high levels of reactive oxygen species(ROS)to kill tumor cells and induce antitumor immunity.However,intracellular antioxidant systems,including glutathione(GSH)system and thioredo...
关键词：Hydroxyethyl starch smart nanomedicine Photodynamic therapy Antioxidant systems Immunogenic cell death 
Carrier-free cryptotanshinone-peptide conjugates self-assembled nanoparticles:An efficient and low-risk strategy for acne vulgaris
《Asian Journal of Pharmaceutical Sciences》2024年第4期85-102,共18页Quanfu Zeng Hongkai Chen Zhuxian Wang Yinglin Guo Yufan Wu Yi Hu Peiyi Liang Zeying Zheng Tao Liang Dan Zhai Yaling Guo Li Liu Chunyan Shen Cuiping Jiang Qun Shen Yankui Yi Qiang Liu 
Acne vulgaris ranks as the second most prevalent dermatological condition worldwide,and there are still insufficient safe and reliable drugs to treat it.Cryptotanshinone(CTS),a bioactive compound derived from traditio...
关键词：Carrier-free CRYPTOTANSHINONE Self-assembly ACNE 
Bispecific antibody drug conjugates:Making 1+1>2被引量：2
《Acta Pharmaceutica Sinica B》2024年第5期1965-1986,共22页Yilin Gu Zhijia Wang Yuxi Wang 
This review was supported by the National Natural Science Foundation of China(82073318);Sichuan Science and Technology Program(2019YFS0003,China);the Support Program of Science&Technology Department of Sichuan Provincial(2023YFSY0046 and 2022NSFSC1365,China).
Bispecific antibody‒drug conjugates(BsADCs)represent an innovative therapeutic category amalgamating the merits of antibody‒drug conjugates(ADCs)and bispecific antibodies(BsAbs).Positioned as the next-generation ADC a...
关键词：Bispecific antibody drug conjugates Antibody drug conjugates Bispecific antibody Targeted therapy SAFETY HER2 EGFR 
Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery被引量：2
《Acta Pharmaceutica Sinica B》2024年第5期2137-2152,共16页Tarik Zahr Vijay K.Boda Jian Ge Lexiang Yu Zhongzhi Wu Jianwen Que Wei Li Li Qiang 
This work was supported by the Columbia University startup packages(Li Qiang and Jianwen Que)and the University of Tennessee College of Pharmacy Drug Discovery Center(Wei Li).
Estrogen is imperative to mammalian reproductivity,metabolism,and aging.However,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain...
关键词：Estrogen receptorβ Aging METABOLISM Skin injury Muscle metabolism Small molecule conjugates Regeneration ADIPOSITY 
Carbon nanotubes targeted to the tumor microenvironment inhibit metastasis in a preclinical model of melanoma
《Bioactive Materials》2024年第4期237-247,共11页Lorena García-Hevia Rym Soltani Jesús González Olivier Chaloin Cécilia Ménard-Moyon Alberto Bianco Mónica L.Fanarraga 
funded by ISCIII Projects ref.PI19/00349,PI22/00030,PI23/00261 co-funded by ERDF/ESF,“Investing in your future”,Ministerio de Ciencia e Innovación ref.TED2021-129248B-100;the Agence Nationale de la Recherche(ANR)through the LabEx project Chemistry of Complex Systems(ANR-10-LABX-0026_CSC);funding from the European Union’s Horizon Europe Research and Innovation Program(Marie Skłodowska-Curie Actions-Doctoral Networks)under the grant agreement 101073025(Melomanes);LGH thanks the Ministry of Innovation and Science of Spain for her Juan de la Cierva Incorporación grant(IJC2020-043746-I).
Despite notable progress in cancer therapy,metastatic diseases continue to be the primary cause of cancer-related mortality.Multi-walled carbon nanotubes(MWCNTs)can enter tissues and cells and interfere with the dynam...
关键词：Carbon nanomaterials Nanofilaments VASCULARIZATION Peptide conjugates ANGIOGENESIS 
Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway被引量：2
《Science China(Life Sciences)》2024年第4期663-679,共17页Yanfang Liu Yan Wang Bing Liu Wenzhong Liu Yuanyuan Ma Yiren Cao Shi Yan Panpan Zhang Lixin Zhou Qimin Zhan Nan Wu 
supported by the National Natural Science Foundation of China (81972842, 82373082, 81988101, 82173152)
Chemoresistance is a significant barrier to effective cancer treatment.Potential mechanisms for chemoresistance include reactive oxygen species(ROS)accumulation and expression of chemoresistance-promoting genes.Here,w...
关键词：CHEMORESISTANCE lncRNARNA interference ROS CHEMOSENSITIZER 
Antibody-platinum(IV)prodrugs conjugates for targeted treatment of cutaneous squamous cell carcinoma
《Journal of Pharmaceutical Analysis》2024年第3期389-400,共12页Xiangye Yin Yingjie Zhuang Haiqin Song Yujian Xu Fan Zhang Jianxin Cui Lei Zhao Yingjie Yu Qixu Zhang Jun Ye Youbai Chen Yan Han 
the National Natural Science Foundation of China(Grant No.:51803120).
Antibody-drug conjugates(ADCs)are a new type of targeting antibodies that conjugate with highly toxic anticancer drugs via chemical linkers to exert high specificity and efficient killing of tumor cells,thereby attrac...
关键词：Antibody drug conjugate Cutaneous squamous cell carcinoma DNA damage Platinum drug Targeted therapy 
Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy
《Asian Journal of Pharmaceutical Sciences》2024年第1期135-146,共12页Sujie Huang Yuxuan Gao Ling Ma Bo Jia Wenhao Zhao Yufan Yao Wenyuan Li Tongyi Lin Rui Wang Jingjing Song Wei Zhang 
supported by the grants from the National Natural Science Foundation of China(Nos.81773566 and 21602092);Innovation Project of Medicine and Health Science and Technology of Chinese Academy of Medical Sciences(2019-I2M-5-074);the Funds for Fundamental Research Creative Groups of Gansu Province(No.20JR5RA310);the Fundamental Research Funds for the Central Universities(No.lzujbky-2021-38).
Melittin,a classical antimicrobial peptide,is a highly potent antitumor agent.However,its significant toxicity seriously hampers its application in tumor therapy.In this study,we developed novel melittin analogs with ...
关键词：Antimicrobial peptide Peptide-drug conjugate Cell-penetrating activity Membrane disruption Antitumor activity 
Discovery and bioassay of disubstituted β-elemene-NO donor conjugates:synergistic enhancement in the treatment of leukemia被引量：2
《Chinese Journal of Natural Medicines》2023年第12期916-926,共11页ZHU Junlong JIANG Xiaoying LUO Xinyu GAO Yuan ZHAO Rui LI Junjie CAI Hong DANG Xiawen YE Xiangyang BAI Renren XIE Tian 
This project was supported by the Natural Science Foundation of Zhejiang province(No.LY20H300004);the National Natural Science Foundation of China(Nos.82073686,81730108,and 81973635);Scientific Research Foundation for Scholars of HZNU(Nos.2021QDL026 and 2019QDL003);the Ministry of Science and Technology of China(High-end foreign experts program,Nos.G20200217005 and G2021017004).
Natural products are essential sources of antitumor drugs.One such molecule,β-elemene,is a potent antitumor compound extracted from Curcuma wenyujin.In the present investigation,a series of novel 13,14-disubstituted ...
关键词：Antitumor activity Chronic myeloid leukemia Β-ELEMENE Nitric oxide donor Structural modification 
Triphenylmethanol Conjugates of Triptorelin as Cell-Penetrating Anti-Cancer Prodrugs
《Journal of Biosciences and Medicines》2023年第11期208-218,共11页Jawzah Alnakhli Samiyah Alhamed William Boadi Ryan Beni 
Some Triptorelin® (TRP) conjugates of triphenylmethanol derivatives (TPMs) with optimized hydrophobicity were synthesized by reacting 2-substituted methoxy benzenes with 1,3,5-trioxane, followed by the conj...
关键词：PRODRUGS TRIPTORELIN POLYPHENOLS Prostate Cancer Triphenylmethanol 
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