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Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells被引量：1
《Signal Transduction and Targeted Therapy》2023年第6期3013-3028,共16页Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying Zhu Jianbo Pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang 
supported by National Natural Science Foundation of China(22137002[Y.D.],32071432[M.T.],81872102[H.J.]);University Innovation Research Group Project of Chongqing(CXQT21016[Y.D.]);High-Level Innovation Platform Project of Chongqing[Y.D.];Talent Program of Chongqing(CQYC202003053[Y.D.]);The collaborative project of Chinese Academy of Sciences institutions and universities in Chongqing(HZ2021006[Y.D.]);Innovative Research Team of High-Level Local Universities in Shanghai(SSMU-ZDCX20181202[M.T.]).
Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for PCa.Here...
关键词：DRUG PC3 diagnosis OPERATIVE 
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes被引量：1
《Signal Transduction and Targeted Therapy》2023年第3期1318-1331,共14页Pedro Casado Ana Rio-Machin Juho JMiettinen Findlay Bewicke-Copley Kevin Rouault-Pierre Szilvia Krizsan Alun Parsons Vinothini Rajeeve Farideh Miraki-Moud David CTaussig Csaba Bödör John Gribben Caroline Heckman Jude Fitzgibbon Pedro R.Cutillas 
We thank Adrian Kontor for technical help with the manipulation of AML primary samples,Sarah Mueller for managing the supply of AML primary samples,Janet Matthews for assisting with the processing of patient clinical data,Ruth Osuntola for technical assistance with the mass spectrometry experiments and the FIMM High Throughput Biomedicine Unit for their expert technical support.This work was mainly funded by Cancer Research UK(C15966/A24375)with additional contribution from Blood Cancer UK(20008).All authors have read and approved the article.
Acute myeloid leukaemia(AML)patients harbouring certain chromosome abnormalities have particularly adverse prognosis.For these patients,targeted therapies have not yet made a significant clinical impact.To understand ...
关键词：metabolism signature biologically 
Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses
《Signal Transduction and Targeted Therapy》2023年第2期341-343,共3页Liyan Sui Letian Li Yinghua Zhao Yicheng Zhao Pengfei Hao Xuerui Guo Wenfang Wang Guoqing Wang Chang Li Quan Liu 
This work was supported by grant from the National Natural Science Foundation of China(81972873,82002165,81871699,and 82072330);the Biosafety Research Special Plan of the Logistics Support Department of the Military Commission(923070201202);the young and middle-aged science and technology innovation leaders and teams of the Jilin Provincial Department of Science and Technology(20200301001RQ);China Ministry of Science and Technology Key Research and Development Program(2022YFF1203204);Jilin Province Pathogen and Infection Informatics International Joint Research Center(20210504004GH);the Pearl River Talent Plan in Guangdong Province of China(2019CX01N111);the Scientific and Technological Research Projects of Guangzhou,China(202103000008);the Medical Innovation Team Project of Jilin University(2022JBGS02).
Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of the COVID-19 pandemic,has posed severe threats to global public health,highlighting an urgent need to understand its patho...
关键词：acute RESPIRATORY cycle 
Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach被引量：4
《Signal Transduction and Targeted Therapy》2022年第8期3054-3068,共15页Xiaoyan Zhang Shan Li Haihua Luo Shuyue He Huangda Yang Lei Li Tian Tian Qizheng Han Jiacong Ye Chenyang Huang Aihua Liu Yong Jiang 
supported by grants from the NSFC-Guangdong Joint Foundation of China(U1601225);the National Natural Science Foundation of China(81671965 and 82130063);Special Support Plan for Outstanding Talents of Guangdong Province(2019JC05Y340);Guangdong Provincial Science and Technology Project(2016A020216015).
Effectively killing pathogenic bacteria is key for the treatment of sepsis.Although various anti-infective drugs have been used for the treatment of sepsis,the therapeutic effect is largely limited by the lack of a sp...
关键词：inhibited ORGANS STRAIN 
EpiMap: Fine-tuning integrative epigenomics maps to understand complex human regulatory genomic circuitry
《Signal Transduction and Targeted Therapy》2021年第6期1627-1629,共3页Dave S.B.Hoon Negin Rahimzadeh Matias A.Bustos 
In a recent paper published in Nature,Boix et al.1 developed an integrated platform on epigenomic maps that represents a significant updated resource in human regulatory circuitry as related to specific organ tissues ...
关键词：MAPS tuning Map 
An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19被引量：2
《Signal Transduction and Targeted Therapy》2021年第5期1585-1600,共16页Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng 
This work was supported in part by the National Natural Science Foundation of China(61872216,81630103,31900862,31725014);Jiangsu Provincial Emergency Project on Prevention and Control of COVID-19 Epidemic(BE2020601);the Nation Science and Technology Major Projects for Major New Drugs Innovation and Development(2018ZX09711003-004-002,2019ZX09301010);Pudong New Area Science and Technology Development Foundation(PKX2019-S08);the Turing Al Institute of Nanjing,and the Zhongguancun Haihua Institute for Frontier Information Technology.
The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed...
关键词：PREVENTION RESPIRATORY ACUTE 
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