supported by the National Key Research and Development Program of China (2022YFF1000500 to K.Z. and2021YFA1101100 to C.S.);Zhejiang Provincial Natural Science Foundation(LZ22C110002 to C.S.);National Natural Science Foundation of China(32271031 to K.Z. and 82230038, 31871203, and 32071032 to C.S.)。
Amyotrophic lateral sclerosis(ALS) is a devastating motoneuron disease,in which lower motoneurons lose control of skeletal muscles.Degeneration of neuromuscular junctions(NMJs) occurs at the initial stage of ALS.Dipep...
Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles.The classical form of this autoimmune disease is characterized by the presence of antibodies against the m...
This work was supported by National Natural Science Foundation of China(Nos.81672247,81772339,8181101445,81811530750,and 81811530389);Shanghai Rising-Star Project(No.18QB1400500),The Key Clinical Medicine Center of Shanghai(No.2017ZZ01006);Sanming Project of Medicine in Shenzhen(No.SZSM201612078);The Introduction Project of Clinical Medicine Expert Team for Suzhou(No.SZYJTD201714);Development Project of Shanghai Peak Disciplines-Integrative Medicine(No.20180101).
The peripheral nervous system(PNS)is essential for performing and maintaining various motor and sensory functions.Abnormalities can lead to a series of peripheral neurological conditions,such as paraesthesia,pain,or s...
转移、侵袭和免疫逃避是肿瘤的重要生物学特性,聚集蛋白Agrin结合低密度脂蛋白受体相关蛋白4(low density density lipoprotein receptor related protein 4,Lrp4),参与肿瘤的侵袭与迁移.此外,Agrin还促进血管形成,并通过α-肌萎缩蛋白...