Autoimmune regulator(AIRE)is a unique transcriptional regulator that induces ectopic expression of thousands of tissue-specific genes in the thymus,a step critical for the establishment of immunological tolerance to s...
supported by the National Natural Science Foundation of China(31970856);the Clinical Frontier Technology Program of the First Affiliated Hospital of Jinan University(JNU1AF-CFTP-2022-a01236);the Science and Technology Program of Guangzhou(202201020042).
The expression of self-antigens in medullary thymic epithelial cells(mTECs)is essential for the establishment of immune tolerance,but the regulatory network that controls the generation and maintenance of the multitud...
Decision tree(DT)plays an important role in pattern recognition and machine learning,which is widely used for regression tasks because of its natural interpretability.Nevertheless,the traditional decision tree is cons...