Startup Fund for Scientific Research,Fujian Medical University(Grant No.2022QH1216)。
Snake venom disintegrins,through their inhibition of integrin-related binding,effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways,rendering them promising candidates ...
Integrins mediate cell adhesion to the extracellular matrix (ECM). In particular, integrin alphavbeta3 recognizes the RGD motif as a ligand-binding site on various extracellular molecules of the extracellular matrix. ...
supported by the National Natural Science Foundation of China(91127026,11074115 and 61101056);the Open Project of State Key Laboratory of Bioelectronics of Southeast University(2011E14);supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions
Decorsin, an antagonist of integrin glycoprotein IIb/IIIa, contains Arg-Gly-Asp (RGD) sequence and three disulfide bridges. The function of RGD sequence has already been well defined, but the roles of conserved disu...
Our findings represent the first report of the antitumor activity of the disintegrin-like components from the venom of Armenian viper (M. raddei). The venom of M. raddei was separated by reverse phase high-performance...