SPHINGOSINE

作品数：80被引量：236H指数：8
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相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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Cystathionineγ-lyase-derived H_(2)S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase
《Acta Pharmacologica Sinica》2024年第11期2366-2379,共14页You-tian Hu Zhi-wei Liu Tong-hui Zhang Yu-e Ma Lei He Jie Zhang Yue-yang Zhou Antonio Vidal-Puig De-jing Pan Fang Wu 
supported by the National Natural Science Foundation of China(32271304,31500635,21834005,31771299);Research Fund of Medicine and Engineering of Shanghai Jiao Tong University(YG2021QN144);National Key R&D Program of China(2018YFA0801100);National Center for International Research of Genomics(2017B01012).
Thymic egress is a crucial process for thymocyte maturation,strictly regulated by sphingosine-1-phosphate lyase(S1PL).Recently,cystathionineγ-lyase(CSE),one of the enzymes producing hydrogen sulfide(H_(2)S),has emerg...
关键词：immune cells thymic egress hydrogen sulfide S1P lyase redox motif NSC4056 
Sphingosine phosphate lyase insufficiency syndrome:a systematic review
《World Journal of Pediatrics》2023年第5期425-437,共13页Zahra Pournasiri Abbas Madani Fatemeh Nazarpack John A.Sayer Zahra Chavoshzadeh Fatemeh Nili Paulina Tran Julie D.Saba Mahnaz Jamee 
Background Sphingosine-1-phosphate lyase insufficiency syndrome(SPLIS)or nephrotic syndrome type-14 is caused by biallelic mutations in SGPL1.Here,we conducted a systematic review to delineate the characteristics of S...
关键词：Nephrotic syndrome type 14 Immunodeficiency LYMPHOPENIA Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase insufficiency syndrome 
Aryl hydrocarbon receptor signaling promotes ORMDL3- dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase被引量：1
《Cellular & Molecular Immunology》2019年第10期783-790,共8页Hsueh-Chun Wang Tzu-Hsuan Wong Li-Ting Wang Hsiang-Han Su Hsiu-Yueh Yu Ai-Hsuan Wu Yu-Chun Lin Hua-Ling Chen Jau-Ling Suen Shih-Hsien Hsu Li-Chen Chen Yufeng Zhou Shau-Ku Huang 
This work was supported,in part,by grants from the National Health Research Institutes,Taiwan(EOPP10-014 and EOSP07-014 to S.-K.H.);Kaohsiung Medical University“The Talent Plan”(105KMUOR04 to S.-K.H.);the Ministry of Science and Technology,Taiwan(MOST 105-2320-B-039-004 and MOST 106-2320-B-039-037,to H.-C.W.);China Medical University Hospital,Taiwan(DMR-106-154 and DMR-107-117,to H.-C.W.);the Community Medicine Research Center,Chang Gung Memorial Hospital at Keelung(CMRPG3E1183 to L.-C.C.);the 1000 Young Talents Plan Program,China(to Y.Z.);the Initial Funding for New PI,Fudan Children’s Hospital and Fudan University(to Y.Z.);the National Natural Science Foundation of China(81671561,to Y.Z.);the National Key Research and Development Program of China(2016YFC1305102,to Y.Z.)。
Aryl hydrocarbon receptor(AhR),a cellular chemical sensor,controls cellular homeostasis,and sphingosine-1-phosphate(S1P),a bioactive intermediate of sphingolipid metabolism,is believed to have a role in immunity and i...
关键词：Aryl hydrocarbon receptor ORMDL sphingolipid biosynthesis regulator 3 Sphingosine-1-phosphate Sphingosine-1-phosphate lyase 
Correction to:Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase
《Cellular & Molecular Immunology》2018年第9期870-870,共1页Hsueh-Chun Wang Tzu-Hsuan Wong Li-Ting Wang Hsiang-Han Su Hsiu-Yueh Yu Ai-Hsuan Wu Yu-Chun Lin Hua-Ling Chen Jau-Ling Suen Shih-Hsien Hsu Li-Chen Chen Yufeng Zhou Shau-Ku Huang 
Overexpression of Rice Sphingosine-1-Phoshpate Lyase Gene OsSPL1 in Transgenic Tobacco Reduces Salt and Oxidative Stress Tolerance被引量：5
《Journal of Integrative Plant Biology》2012年第9期652-662,共11页Huijuan Zhang Jing Zhai Jibo Mo Dayong Li Fengming Song 
supported by the National Key Project for Research on Transgenic Plants (2009ZX08001-017B and 2011ZX08009-003-001);the National Natural Science Foundation of China (No. 30971880);the National High-tech R&D Program of China (No. 2 012AA101504);the Program for Changjiang Scholars and Innovative Research Team in the University of the Ministry of Education of China (No. IRT0943)
Sphingolipids, including sphingosine-l-phosphate （SIP）, have been shown to function as signaling mediators to regulate diverse aspects of plant growth, development, and stress response. In this study, we performed f...
关键词：SPHINGOLIPIDS sphingosine-l-phosphate lyase （SPL） OsSPL1 salt stress oxidative stress. 
Molecular and Functional Characterization of Sphingosine-1-Phosphate Lyase Homolog from Higher Plants被引量：3
《Journal of Integrative Plant Biology》2007年第3期323-335,共13页Yan Niu Kunling Chen Jizhou Wang Xin Liu Huanju Qin Aimin Zhang Daowen Wang 
Supported by the National Natural Science Foundation of China （30521001） and the Chinese Academy of Sciences （KSCX2-SW-304）.Acknowledgments The authors are grateful to Drs Lu Liang and Yiping Tong for helpful discussion on this work and the writing of the manuscript.
Sphingosine-1-phosphate lyase （SPL） is involved in degrading the conserved sphingolipid signaling molecule sphingosine-1-phosphate. However, molecular studies on plant SPL have not been reported to date. Here, we pr...
关键词：Arabidopsis cell death leaf development and senescence rice SPHINGOLIPID sphingosine-l-phosphate lyase 
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