SPHINGOSINE

作品数：80被引量：236H指数：8
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相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Sphingosine-1-phosphate,a novel TREM2 ligand,promotes microglial phagocytosis to protect against ischemic brain injury被引量：8
《Acta Pharmaceutica Sinica B》2022年第4期1885-1898,共14页Tengfei Xue Juan Ji Yuqin Sun Xinxin Huang Zhenyu Cai Jin Yang Wei Guo Ruobing Guo Hong Cheng Xiulan Sun 
supported by the National Natural Science Foundation of China (Nos.81973301, 82003732 and 81773701);the Medical Research Project of Jiangsu Commission of Health (No.ZDA2020006, China);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No.18KJA310004);the Major Project of Nanjing Medical University (No.NMUD2018008, China);the Postgraduate Research and Practice Innovation Program of Jiangsu Province (Nos.KYCX19_1121 and KYCX20_1417, China);Priority Academic Program Development of Jiangsu Higer Education Institutions (China)
The mechanism of sphingosine-1-phosphate(S1P)-mediated phagocytosis remains unknown.Here,we found that S1P or FTY720(an analog of S1P)promoted microglial phagocytosis in stroke independent of S1PRs.First,we used compu...
关键词：S1P TREM2 MICROGLIA PHAGOCYTOSIS Stroke APOE LRP1B Apoptotic neurons 
Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates
《Acta Pharmaceutica Sinica B》2020年第6期1134-1142,共9页Qiong Xiao Minwan Hu Si Chen Yifan Tang Zeyu Shi Jing Jin Jinping Hu Ping Xie Dali Yin 
financially supported by the Drug Innovation Major Project(No.2018ZX09711001-005-012,China);National Key R&D Program of China(No.2018YFC1706403);CAMS Innovation Fund for Medical Sciences(No.2016-I2M-2-002,China);Disciplines construction project(No.201920200802,China)
FTY720 and IMMH002,prodrugs for sphingosine-1-phosphate receptor 1(S1P1)agonists,show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats.In this study,FTY720 or IMMH002 analogues(...
关键词：S1P1 agonist PRODRUG Catalytic amination Phosphate formation rate LYMPHOCYTE 
An efficient method for preparing the sphingosine-1-phosphate receptor agonist, KRP203-phosphate
《Chinese Chemical Letters》2013年第9期817-820,共4页Xiao-Jian Wang Jian-Guo Qi Gang Li Yu-Lin Tian Da-Li Yin 
financially supported by National Natural Science Foundation of China(No.81102322)
An efficient method for mono-phosphorylation of 2 （KRP203） using cbz-protection, dibenzylphosphoryl chloride and TMSI affording 2-P （KRP203-P） was developed. We applied the present method to the synthesis of KRP20...
关键词：Mono-phosphorylation TMSI KRP203-P 
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