RIBONUCLEOPROTEINS

作品数：4被引量：12H指数：2
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相关期刊：《Science China(Life Sciences)》《Cell Research》《Acta Pharmaceutica Sinica B》《Journal of Genetics and Genomics》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein(RNP)to inhibit herpes simplex virus1 infection in vitro and in vivo
《Acta Pharmaceutica Sinica B》2024年第3期1362-1379,共18页Yuanda Wan Liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao 
supported by the Guangdong Basic and Applied Basic Research Foundation(2023A1515030057,Xingang Yao);the National Natural Science Foundation of China(82373873,Xingang Yao)。
Extracellular vesicles(EVs)have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins(RNPs),owing to their ability to minimize off-target effects and immune responses.However,enhancement...
关键词：Extracellular vesicles CRISPR/Cas9 RIBONUCLEOPROTEINS PTGFRN Fc/Spa HSV1 Neuron-targeting Delivery 
A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection被引量：10
《Science China(Life Sciences)》2022年第8期1535-1546,共12页Kui Xu Xiuling Zhang Zhiguo Liu Jinxue Ruan Changjiang Xu Jingjing Che Ziyao Fan Yulian Mu Kui Li 
supported by the National Natural Science Foundation of China (32072690);the Major Scientific Research Tasks for Scientific and Technological Innovation Projects of the Chinese Academy of Agricultural Sciences (CAAS-ZDRW202006);the Science, Technology and Innovation Commission of Shenzhen Municipality (JCKYZDKY202009);the National Transgenic Breeding Project (2016ZX08010-004);the National Transgenic Breeding Project (2016ZX08006-001);the Agricultural Science and Technology Innovation Program (ASTIP-IAS05)。
Gene-edited pigs for agricultural and biomedical applications are typically generated using somatic cell nuclear transfer(SCNT).However, SCNT requires the use of monoclonal cells as donors, and the time-consuming and ...
关键词：dual-sg RNA CRISPR-Cas9 ribonucleoproteins transgene-free without monoclonal selection cloned pig 
Cost-effective generation of A-to-G mutant mice by zygote electroporation of adenine base editor ribonucleoproteins被引量：2
《Journal of Genetics and Genomics》2020年第6期337-340,共4页Hongwei Sun Shengyao Zhi Guifang Wu Guanglan Wu Tianqi Cao Hu Hao Zhou Songyang Puping Liang Junjiu Huang 
supported by the National Key R&D Program of China(2017YFC1001901,2017YFA0102801 and 2017YFC1001603);the National Natural Science Foundation of China(91640119,31671540,81330055 and 31601196);the Guangdong Special Support Program(2019BT02Y276);the Natural Science Foundation of Guangdong Province(2016A030310206 and 2014A030312011);the Science and Technology Planning Project of Guangdong Province(2015B020228002);the Guangzhou Science and Technology Project(201707010085 and 201803010020)。
More than 32,000 pathogenic single nucleotide polymorphisms(SNPs)have been identified in the human genome(Gaudelli et al.,2017).Genetically modified mice with pathogenic SNPs are good models for studies of disease pat...
关键词：al. EDITOR pathogenesis 
Structural components of the nuclear body in nuclei of Allium cepa cells
《Cell Research》2001年第1期68-73,共6页TAO WEI, CHANG HUI YAN, TAO CAI, SHUI HAO, ZHONG HE ZHAI (College of Life Sciences, Peking University, Beijing 100871, China) (Institute of Genetics and Cytology, Northeast Normal University, Changchun Jilin 130024, China) 
Nuclear bodies have long been noted in interphase nuclei of plant cells, but their structural component, origin and function are still unclear by now. The present work showed in onion cells the nuclear bodies appeared...
关键词：Pol1 Transcription Initiation Complex Proteins Cell Nucleolus Cell Nucleus DNA DNA-Binding Proteins INTERPHASE Microscopy  Electron Onions Plant Components RNA  Messenger Research Support  Non-U.S. Gov't RIBONUCLEOPROTEINS Silver Staining Transcription Factors 
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