supported by the National Key Research and Development Program of China(2021YFC2701100);the National Natural Science Foundation of China(81930036,32293230 and 8215008);the Commission for Science and Technology of Shanghai Municipality(20JC1418500 and 20ZR1404800);Project supported by Shanghai Municipal Science and Technology Major Project。
Heparan sulfate proteoglycan 2(HSPG2)gene encodes the matrix protein Perlecan,and genetic inactivation of this gene creates mice that are embryonic lethal with severe neural tube defects(NTDs).We discovered rare genet...