supported by the National Natural Science Foundation of China(No.30900290;31270993);Program for New Century Excellent Talents in Universities of Ministry of Education;China(No.NCET-10-0922);the Natural Science Foundation of Shandong Province;China(No.ZR2009CQ027;ZR2011CQ030);the Medicine and Health Science and Technology Project of Shandong Province;China(No.2011QZ024)