In a recent paper published in Cell Research,Cai et al.report development of the prodrug senescence-specific killing compound 1(SSK1),which specifically clears SA-β-galactosidase-positive senescent cells both in vitr...
This work was supported by National Key Research and Development Program of China(2017YFA0104003,2017YFA0103000);the National Natural Science Foundation of China(22040102 and 31521004 to H.D.and T.L.,31730059 to H.D.,21672011 and 21822101 to T.L.).
Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease ch...