supported by the Youth Project of National Natural Science Foundation of China(No.31200836);the Natural Science Foundation for Colleges and Universities in Jiangsu Province;China(No.12KJD320005);Zhen Xing Project/the Special Talent Fund of Dean of Xuzhou Medical College;Jiangsu Province;China(No.2012KJZ15)
目的:观察背根节慢性压迫(chronic compression of dorsal root ganglion,CCD)大鼠脊髓内高迁移率蛋白-1(high mobility group box-1,HMGB1)的变化,探讨其参与痛觉信息传递的机制,为慢性痛的治疗提供新的思路和靶点。方法:(1)24只SD大...
supported by a grant from Parker Research Foundation(PRF-BSR10110607)
背根节(dorsal root ganglion,DRG)损伤或炎症可导致DRG神经元兴奋性异常增强和痛觉过敏。我们近期研究显示,长期慢性在体压迫(chronic compression of DRG,CCD)或急性离体分离(acute dissociation of DRG,ADD)背根节导致的神经元兴奋...