supported by the National Key Research and Development Program of China(2021YFC2701100);the National Natural Science Foundation of China(81930036,32293230 and 8215008);the Commission for Science and Technology of Shanghai Municipality(20JC1418500 and 20ZR1404800);Project supported by Shanghai Municipal Science and Technology Major Project。
Heparan sulfate proteoglycan 2(HSPG2)gene encodes the matrix protein Perlecan,and genetic inactivation of this gene creates mice that are embryonic lethal with severe neural tube defects(NTDs).We discovered rare genet...
supported by the Chinese Ministry of Science and Technology(2015CB964501 and2014CB964903);the National Natural Science Foundation of China(31371477);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01020301)
Mammalian cortical development is a dynamically and strictly regulated process orchestrated by extracellular signals and intracellular mechanisms. Recent studies show that epigenetic regulation serves as, at least in ...
supported by the State“863"High-Tech Project(Grant Nos.2002AA205051 and 2001 AA216l5l);the National Key Project for Basic Research of China(Grant No.001CB509906);the Project of Beijing Science Community(Grant No.020220010190).
Neural stem cell (NSC) is the progenitor of the neural system with the character of self-renew and hav-ing the potential to differentiate into all the phenotypes in the central nervous system (CNS). NSC may serve as a...