This trial was supported by the National Natural Science Foundation of China(81720108002);the National Science and Technology Major Project(2018ZX09734-007);Excellent Youth Foundation Project of Jiangsu Province(Grant No.BK20160099);Translational Research Grant of NCRCH(2020ZKZB01);CSCO Research Foundation(Y-Roche2019/2-0090).
This study(ORIENT-4)aimed to assess the efficacy and safety of sintilimab,a humanized anti-PD-1 antibody,in patients with relapsed/refractory extranodal NK/T cell lymphoma(r/r ENKTL).ORIENT-4 is a multicenter,single-a...
financially supported by the National Natural Science Foundation of China (No. 51573020);Beijing Natural Science Foundation (No. 2172022);Scientific Research Project of Beijing Educational Committee (No. KM201810017008);Project of Petrochina (No. kywx-18-002);URT program (No. 2018J00074)
The low-activity cationic monomer tert-butyl-dimethyl-(4-methyl-pent-4-enyloxy)-silane was synthesized by Grignard reaction and hydroxyl-protection reaction. Living polyisobutylene chains were initially synthesized by...