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作品数：376被引量：256H指数：7
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相关机构：郑州大学河南工业大学河南大学华东师范大学更多>>
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Rhodium(Ⅲ)-catalyzed [4+2] annulation of N-arylbenzamidines with1,4,2-dioxazol-5-ones: Easy access to 4-aminoquinazolines via highly selective C-H bond activation
《Chinese Chemical Letters》2021年第8期2592-2596,共5页Jie Ren Yanzhen Huang Chao Pi Xiuling Cui Yangjie Wu 
financial support from the Ministry of Science and Technology of China (No.2016YFE0132600);Henan Center for Outstanding Overseas Scientists (No.GZS2020001);Zhengzhou University。
A novel approach for the synthesis of 4-aminoquinazolines has been developed via rhodium(Ⅲ)-catalyzed [4+2] annulation of N-arylbenzamidines with 1,4,2-dioxazol-5-ones.This reaction features excellent regioselectivit...
关键词：[4+2]Annulation N-Arylbenzamidine 4-Aminoquinazoline Excellent regioselectivity High step economy 
Climate change has more adverse impacts on the higher mountain communities than the lower ones: people’s perception from the northern Himalayas被引量：1
《Journal of Mountain Science》2019年第11期2625-2639,共15页HUANG Xiao-hui ZHOU Yao-zhi FANG Jiang-ping HOU Lei 
funded by Tibet Autonomous region Department of Science and Technology(2016ZR-NZ-01);the Ministry of Science and Technology of China(2016YFC0502006)
The Himalayas are assumed to experience rapid climate change,with serious environmental,social and economic consequences for people living in and around the mountain area.However,the extent of climate change and its i...
关键词：Northern HIMALAYAN Climate change PERCEPTION ELEVATION gradient TIBET 
The design, synthesis and α7 nicotinic acetylcholine receptors positive allosteric modulative evaluation of 3H-quinazolin-4-one derivatives被引量：1
《Journal of Chinese Pharmaceutical Sciences》2018年第8期540-552,共13页Zongze Huang Xintong Wang Ying Meng Xin Li Haoran Xiao Xiling Bian KeWei Wang Qi Sun 
National Natural Science Foundation of China(NSFC,Grant No.21572011);Ministry of Science and Technology of China(Grant No.2013CB531302)
A series of new 6-substituted 3 H-quinazolin-4-ones（3 a-3 d） were designed, synthesized and evaluated as the type I positive allosteric modulators（PAMs） of human α7 n ACh R expressed in Xenopus ooctyes by two-ele...
关键词：3H-Quinazolin-4-ones α7 nAChR Positive allosteric modulators Structure-activity relationship Schizophrenia disease 
Discovery and structural optimization of 4-（ 4-（ benzyloxy）p henyl）-3,4-dihyd ropyrimidin-2（1H ）- ones as RORc inverse agonists被引量：1
《Acta Pharmacologica Sinica》2016年第11期1516-1524,共9页Xi-shan WU Rui WANG Yan-li XING Xiao-qian XUE Yan ZHANG Yong-zhi LU Yu SONG Xiao-yu LUO Chun WU Yu-lai ZHOU Jian-qin JIANG Yong XU 
We gratefully acknowledge financial support partly from the National Natural Science Foundation of China （81373325）, the ＂100 Talents Project＂ of Chinese Academy of Sciences, the Natural Science Foundation of Guangdong Province （c15140600000016）, the Guangzhou Healthcare Collaborative Innovation Programs （201508020255）, the Chinese Academy of Sciences Cloud Platform for Stem Cell and BiomedicalResearch （XXH12503-05-06）, the National Key Basic Research Program of China （973 Program, 2013CB910601） and Bureau of Science and Information Technology of Guangzhou Municipality （2013J4500008）. The authors gratefully acknowledge support from the Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences.
Aim： Retinoic acid receptor-related orphan nuclear receptors （RORs） are orphan nuclear receptors that show constitutive activity in the absence of ligands. Among 3 subtypes of RORs, RORc is a promising therapeutic ...
关键词：nuclear receptor RORC inverse agonist SAR structure-based optimization autoimmune disease 
A Selective Synthesis of 2-Alkylamino-5, 6, 7, 8-tetrahydro-benzothieno[2, 3-d]pyrimidin-4(3H)-ones被引量：1
《Chinese Chemical Letters》2005年第2期189-192,共4页MingWuDING RuiJunXU JingXU YunFengCHEN 
We gratefully acknowledge financial support of this work by the National Key Project for Basic Research(2003CB114400,2003CB114406);the National Natural Science Foundation of China(Project No.20102001).
Alkylamino-5, 6, 7, 8-tetrahydrobenzothieno [2, 3-d] pyrimidin-4(3H)-ones 7 weresynthesized by a new selective synthetic method, which includes aza-Wittig reaction of imino-phosphorane 4 with aromatic isocynate to giv...
关键词：Benzothieno[2 3-d]pyrimidin-4(3H)-ones aza-Wittig reaction iminophosphorane carbodiimide synthesis. 
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