supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
Background:The ORAI family of proteins,comprising ORAI1,ORAI2,and ORAI3,plays a crucial role in the regulation of intracellular calcium signaling,which is essential for various cellular functions including proliferati...
National Natural Science Foundation of China(81173596);and Major Project of Natural Science Foundation of the Department of Education of Anhui Province(KJ2019ZD32)。
OBJECTIVE To explore the effect of total flavonoids of Rhododendra simsii(TFR)on improving cerebral ischemia/reperfusion injury(CIRI)and its relationship with STIM/Orai-regulated operational Ca^(2+)influx(SOCE)pathway...
Optogenetic control of the Ca^(2+)signaling machinery has been a powerful approach but requires complex cell manipulation to introduce modified genes.A newly developed non-invasive,ultrafast laser technique allows for...
This study was supported by grants from the National Natural Science Foundation of China(No.81801175 and No.81970722);the Fundamental Research Funds for the Central Universities(No.WK9110000044 and No.WK9110000036);China Scholarship Council(No.201706270155);the China Postdoctoral Science Foundation(No.2019M662179);the Anhui Province Postdoctoral Science Foundation(No.2019B324).
Summary:Dexmedetomidine(DEX),a potent and highly selective agonist for a2-adrenergic receptors(a2AR),exerts neuroprotective effects by reducing apoptosis through decreased neuronal Ca^2+influx.However,the exact action...