目的:探讨Ca2+-活化T细胞核因子(nuclear factors of activated T cells,NFAT)信号通路在骨髓基质细胞介导的费城染色体阳性(Ph+)急性淋巴细胞白血病(ALL)耐药中的作用。方法:聚合酶链式反应检测Sup-B15细胞及Ph+ALL原代细胞NFAT mRNA...
This work was supported by grants from the National Natural Science funds (No. 81500103), Natural Science Foundation of Jiangsu Province (BK-20151230), and the high-level medical talents training project (No. 2016CZLJ027).
To the Editor:The t(9;22)(q34;q 11) (Philadelphia chromosome [Ph]) balanced translocation results in fusion of the BCR gene at 22q11 with cytoplasmic tyrosine kinase gene ABL1 and plays an essential role in leu...