PHOSPHATASE

作品数：255被引量：886H指数：14
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相关领域：医药卫生生物学更多>>
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相关机构：中国科学院遗传与发育生物学研究所山东大学湖北中医药大学安徽中医学院第一附属医院更多>>
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WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation被引量：10
《Neuroscience Bulletin》2017年第3期292-298,共7页Dahu Li Lijun Zhang Xin Huang Lili Liu Yunling He Lun Xu Yiyao Zhang Tong Zhao Liying Wu Yongqi Zhao Kuiwu Wu Yan Wu Ming Fan Lingling Zhu 
supported by the National Natural Science Foundation of China(31401000 and 81430044);the Youth Medicine Program of the People’s Liberation Army of China(13QNP148);the National Basic Research Development Program(973 Program)of China(2012CB518200);the Integrated Drug Discovery Technology Platform of National Science and Technology Major Projects for‘‘Major New Drugs Innovation and Development’’,China(2012ZX09J12201-005)
The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unkno...
关键词：Hypobaric hypoxia Inflammation Brain injury WIP1 phosphatase Lipopolysaccharide 
Environmental factors in the development and progression of late-onset Alzheimer's disease被引量：6
《Neuroscience Bulletin》2014年第2期253-270,共18页Moses N. Wainaina Zhichun Chen Chunjiu Zhong 
supported by National Basic Research Development Program(973 Program)of China(2011CBA00400);the National Natural Science Foundation of China(91332201);the Natural Science Foundation of Shanghai Municipality,China(13JC1401500);the Fund for Medical Emerging Cutting-edge Technology of Shanghai Municipality,China(SHDC12012114)
Late-onset Alzheimer＇s disease （LOAD） is an age-related neurodegenerative disorder characterized by gradual loss of synapses and neurons, but its pathogenesis remains to be clarified. Neurons live in an environment...
关键词：Alzheimer＇s disease environmental factors corticotrophin-releasing factor CEREBROVASCULAR metatoxicity GLIA astrocyte microglia AI3 kinase PHOSPHATASE tau HYPERPHOSPHORYLATION epigenetic modificationDNA methylation histone acetylation 
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