BACKGROUND Tacrolimus(FK506)is a key calcineurin inhibitor used to prevent organ transplant rejection and is effective in improving graft survival.However,it is linked to hyperglycemia and insulin resistance,contribut...
supported by the National Natural Science Foundation of China, No. 81771140 (to YDZ);the Natural Science Foundation of Jiangsu Province of China, No. BK20201117 (to YDZ);Jiangsu “Six One Project” for Distinguished Medical Scholars of China, No. LGY2020013 (to TJ)
Lamotrigine(LTG)is a widely used drug for the treatment of epilepsy.Emerging clinical evidence suggests that LTG may improve cognitive function in patients with Alzheimer’s disease.However,the underlying molecular me...
This project was supported by National Natural Science Foundation of China(No.31870772).
Alzheimer’s disease(AD)is an age-related neurodegenerative disease with two major hallmarks:extracellular amyloid plaques made of amyloid-β(Aβ)and intracellular neurofibrillary tangles(NFTs)of abnormally hyperphosp...
This work was supported by Institut National de la Santéet la Recherche Médicale(INSE RM),the French National Research Agency(ANR-16-CE18–0010);Fondation NRJ(Institut de France)to NSY and grants CA46462 and CA112278 from the National Institute of Health to JDE and YT.
Background:Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments.Tauopathies are characterized by path...
Alzheimer's disease (AD) is a neurodegenerative disease with proteopathy characterized by abnormalities in amyloid beta (Aβ) and tau proteins. Defective amyloid and tau propagate and aggregate, leading to eventual am...
Intracerebroventricular administration (ICV) of streptozotocin (STZ) in rats has been associated to desensitization of the insulin receptor (IR) and biochemical changes similar to those occurring in Alzheimer’s disea...
supported by grants from the National Natural Science Foundation of China(No.81301000);Postdoctoral Science Foundation of China(No.2016M590696)
Neurofibrillary pathology of abnormally hyperphosphorylated tau is a hallmark of Alzheimer's disease(AD) and other tauopathies.Phosphatidylinositol 3-kinase(PI3K)/Akt/glycogen synthase kinase-3 beta(GSK-3β) si...
Supported by the National Natural Science Foundation(30972831);the China Postdoctoral Science Foundation(2013M530880)
Objective To explore the possible neurophysiologic mechanisms of propofol and N-methyl-Daspartate(NMDA) receptor antagonist against learning-memory impairment of depressed rats without olfactory bulbs. Methods Models ...
supported by National Basic Research Development Program(973 Program)of China(2011CBA00400);the National Natural Science Foundation of China(91332201);the Natural Science Foundation of Shanghai Municipality,China(13JC1401500);the Fund for Medical Emerging Cutting-edge Technology of Shanghai Municipality,China(SHDC12012114)
Late-onset Alzheimer's disease (LOAD) is an age-related neurodegenerative disorder characterized by gradual loss of synapses and neurons, but its pathogenesis remains to be clarified. Neurons live in an environment...
supported by the National Basic Research Program of China (Grant Nos. 2010CB912303 and 2006CB500703);the National Natural Science Foundation of China (Grant No. 30970695); the Knowledge Innovation Project of Chinese Academy of Sciences (Grant Nos. KSCX2-YW-R-256 and CAS-KSCX2-YW-R-119)
Formaldehyde,one of the most toxic organic compounds,is produced and processed in human cells.The level of human endogenous formaldehyde is maintained at a low concentration(0.01-0.08 mmol L-1 in blood) under physiolo...