HYPERPHOSPHORYLATION

作品数:17被引量:64H指数:4
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相关领域:医药卫生生物学更多>>
相关作者:杨万勇董大伟张玉生徐安定更多>>
相关机构:天津中医药大学暨南大学附属第一医院更多>>
相关期刊:《Advances in Alzheimer's Disease》《中国生物学文摘》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金上海市自然科学基金更多>>
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Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells
《World Journal of Diabetes》2025年第2期175-182,共8页Hao-Yan Li Yi Wang Min Ran Fei Gao Bo-Yu Zhu Hai-Ying Xiao Chun Xu 
BACKGROUND Tacrolimus(FK506)is a key calcineurin inhibitor used to prevent organ transplant rejection and is effective in improving graft survival.However,it is linked to hyperglycemia and insulin resistance,contribut...
关键词:TACROLIMUS Insulin resistance DYSLIPIDEMIA Ribosomal protein S6 kinase beta-1 Glucose metabolism 
Lamotrigine protects against cognitive deficits,synapse and nerve cell damage,and hallmark neuropathologies in a mouse model of Alzheimer’s disease被引量:1
《Neural Regeneration Research》2023年第1期189-193,共5页Xin-Xin Fu Rui Duan Si-Yu Wang Qiao-Quan Zhang Bin Wei Ting Huang Peng-Yu Gong Yan E Teng Jiang Ying-Dong Zhang 
supported by the National Natural Science Foundation of China, No. 81771140 (to YDZ);the Natural Science Foundation of Jiangsu Province of China, No. BK20201117 (to YDZ);Jiangsu “Six One Project” for Distinguished Medical Scholars of China, No. LGY2020013 (to TJ)
Lamotrigine(LTG)is a widely used drug for the treatment of epilepsy.Emerging clinical evidence suggests that LTG may improve cognitive function in patients with Alzheimer’s disease.However,the underlying molecular me...
关键词:Alzheimer’s disease Alzheimer’s disease-related neuropathologies amyloid-βpathology APP/PS1 mice cognitive deficits damage of synapses and nerve cells high-throughput RNA sequencing LAMOTRIGINE neuroinflammation tau protein hyperphosphorylation 
Tau in Alzheimer’s Disease:Pathological Alterations and an Attractive Therapeutic Target被引量:3
《Current Medical Science》2020年第6期1009-1021,共13页Jian-lan GU Fei LIU 
This project was supported by National Natural Science Foundation of China(No.31870772).
Alzheimer’s disease(AD)is an age-related neurodegenerative disease with two major hallmarks:extracellular amyloid plaques made of amyloid-β(Aβ)and intracellular neurofibrillary tangles(NFTs)of abnormally hyperphosp...
关键词:Alzheimer’s disease tau protein HYPERPHOSPHORYLATION propagation of tau pathology 
Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy被引量:1
《Translational Neurodegeneration》2018年第1期54-62,共9页Seyedeh Maryam Alavi Naini Constantin Yanicostas Rahma Hassan-Abdi Sébastien Blondeel Mohamed Bennis Ryan J.Weiss Yitzhak Tor Jeffrey D.Esko Nadia Soussi-Yanicostas 
This work was supported by Institut National de la Santéet la Recherche Médicale(INSE RM),the French National Research Agency(ANR-16-CE18–0010);Fondation NRJ(Institut de France)to NSY and grants CA46462 and CA112278 from the National Institute of Health to JDE and YT.
Background:Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments.Tauopathies are characterized by path...
关键词:TAUOPATHY ZEBRAFISH Alzheimer’s disease TAU protein TAU HYPERPHOSPHORYLATION Surfen Oxalyl surfen Heparan sulfate 
Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer's disease被引量:2
《Neuroimmunology and Neuroinflammation》2017年第12期263-271,共9页Lindsay H.Burns Hoau-Yan Wang 
Alzheimer's disease (AD) is a neurodegenerative disease with proteopathy characterized by abnormalities in amyloid beta (Aβ) and tau proteins. Defective amyloid and tau propagate and aggregate, leading to eventual am...
关键词:Proteopathy HYPERPHOSPHORYLATION α7 NICOTINIC ACETYLCHOLINE RECEPTOR TOLL-LIKE RECEPTOR 4 NEUROINFLAMMATION PTI-125 
Role of GSK3<i>β</i>and PP2A on Regulation of Tau Phosphorylation in Hippocampus and Memory Impairment in ICV-STZ Animal Model of Alzheimer’s Disease被引量:3
《Advances in Alzheimer's Disease》2017年第1期13-31,共19页Teresa Ponce-Lopez Enrique Hong Manuel Abascal-Díaz Alfredo Meneses 
Intracerebroventricular administration (ICV) of streptozotocin (STZ) in rats has been associated to desensitization of the insulin receptor (IR) and biochemical changes similar to those occurring in Alzheimer’s disea...
关键词:Memory Deficit Tau HYPERPHOSPHORYLATION GSK3β PP2A STREPTOZOTOCIN HIPPOCAMPUS 
TPPU Protects Tau from H_2O_2-induced Hyperphosphorylation in HEK293/tau Cells by Regulating PI3K/AKT/GSK-3β Pathway被引量:1
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第6期785-790,共6页En-sheng YAO Yan TANG Xing-hua LIU Ming-huan WANG 
supported by grants from the National Natural Science Foundation of China(No.81301000);Postdoctoral Science Foundation of China(No.2016M590696)
Neurofibrillary pathology of abnormally hyperphosphorylated tau is a hallmark of Alzheimer's disease(AD) and other tauopathies.Phosphatidylinositol 3-kinase(PI3K)/Akt/glycogen synthase kinase-3 beta(GSK-3β) si...
关键词:TPPU TAU GSK-3Β Alzheimer's disease 
Propofol can Protect Against the Impairment of Learning-memory Induced by Electroconvulsive Shock via Tau Protein Hyperphosphorylation in Depressed Rats
《Chinese Medical Sciences Journal》2015年第2期100-107,共8页Wan-fu Liu Chao Liu 
Supported by the National Natural Science Foundation(30972831);the China Postdoctoral Science Foundation(2013M530880)
Objective To explore the possible neurophysiologic mechanisms of propofol and N-methyl-Daspartate(NMDA) receptor antagonist against learning-memory impairment of depressed rats without olfactory bulbs. Methods Models ...
关键词:PROPOFOL Tau protein learning-memory ABILITIES GLUTAMATE electroconvulsive therapy 
Environmental factors in the development and progression of late-onset Alzheimer's disease被引量:6
《Neuroscience Bulletin》2014年第2期253-270,共18页Moses N. Wainaina Zhichun Chen Chunjiu Zhong 
supported by National Basic Research Development Program(973 Program)of China(2011CBA00400);the National Natural Science Foundation of China(91332201);the Natural Science Foundation of Shanghai Municipality,China(13JC1401500);the Fund for Medical Emerging Cutting-edge Technology of Shanghai Municipality,China(SHDC12012114)
Late-onset Alzheimer's disease (LOAD) is an age-related neurodegenerative disorder characterized by gradual loss of synapses and neurons, but its pathogenesis remains to be clarified. Neurons live in an environment...
关键词:Alzheimer's disease environmental factors corticotrophin-releasing factor CEREBROVASCULAR metatoxicity GLIA astrocyte microglia AI3 kinase PHOSPHATASE tau HYPERPHOSPHORYLATION epigenetic modificationDNA methylation histone acetylation 
Formaldehyde stress被引量:19
《Science China(Life Sciences)》2010年第12期1399-1404,共6页HE RongQiao LU Jing MIAO JunYe 
supported by the National Basic Research Program of China (Grant Nos. 2010CB912303 and 2006CB500703);the National Natural Science Foundation of China (Grant No. 30970695); the Knowledge Innovation Project of Chinese Academy of Sciences (Grant Nos. KSCX2-YW-R-256 and CAS-KSCX2-YW-R-119)
Formaldehyde,one of the most toxic organic compounds,is produced and processed in human cells.The level of human endogenous formaldehyde is maintained at a low concentration(0.01-0.08 mmol L-1 in blood) under physiolo...
关键词:FORMALDEHYDE Alzheimer’s disease senile dementia STRESS COGNITION IMPAIRMENT HYPERPHOSPHORYLATION 
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