PRIONS

作品数：9被引量：15H指数：2
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相关领域：医药卫生农业科学更多>>
相关作者：林键更多>>
相关机构：中山大学更多>>
相关期刊：《中山大学研究生学刊（自然科学与医学版）》《World Journal of Gastroenterology》《World Journal of Biological Chemistry》《Science Bulletin》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划更多>>
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Prions:a threat to health security and the need for effective medical countermeasures
《Global Health Journal》2023年第1期43-48,共6页Ying-Chiang J.Lee 
Prions are infectious conformations of certain naturally occurring proteins.These misfolded proteins can struc­turally alter healthy protein,creating misfolded copies that repeat the process and form protein aggregate...
关键词：PRIONS Medical countermeasures Interventions Vaccines BIOSECURITY Policy 
Research Progress on Harmless Treatment of Dead Livestock and Poultry with Alkaline Hydrolysis in China
《Animal Husbandry and Feed Science》2017年第6期346-348,354,共4页Zhang Zhenling Xu Haifei Sun Peng Zhao Bingkai Dong Shuhong 
Surported by Jiangsu Vocational Colleges Young Teachers Enterprise Practice Training Funding Project(2016QYSJ058);Xuzhou Vocational College of Bioengineering 2017 Science and Technology Project-A Preliminary Study on Farm Animal Welfare(2017KY07);Xuzhou Vocational College of Bioengineering Animal Husbandry and Veterinary Brand Profession Construction Fund
China＇s animal husbandry industry has developed rapidly and the inventory of swine, poultry, and sheep has been in the first place in the world of late years. For several consecutive years, the annual slaughter swine...
关键词：Carcasses of livestock and poultry Alkalization hydrolysis Harmless disposal technology PRIONS 
Major hotspots detected along the Scotia Ridge in autumn for southern right whales Eubalaena australis, Antarctic fur seals Arctocephalus gazella and Antarctic prions Pachyptila desolata被引量：1
《Advances in Polar Science》2015年第4期282-291,共10页Claude R.Joiris Grant R.W.Humphries Diederik D'Hert René-Marie Lafontaine Henri Robert Roseline C.Beudels-Jamar 
We investigated the role of hydrological features, such as water masses, fronts, eddies, and sea ice, in affecting the distribution of upper trophic level species in the Scotia Sea region during autumn. On board RV Po...
关键词：Scotia Sea Scotia Ridge Scotia Trench seabirds ＆ marine mammals southern right whale Antarcticfur seal Antarctic prion 
Techniques to elucidate the conformation of prions
《World Journal of Biological Chemistry》2015年第3期218-222,共5页Martin L Daus 
Supported by Alberta Prion Research Institute,Canada(Project title:"Comprehensive Risk Assessment of CWD Transmission to Humans Using Non-human Primates");European Metrology Research Programme(EMRP);Researcher Grant:HLT10-Bi Origin(Metrology for the Biomolecular Origin of Disease)
Proteinaceous infectious particles(prions) are unique pathogens as they are devoid of any coding nucleic acid.Whilst it is assumed that prion disease is transmitted by a misfolded isoform of the cellular prion protein...
关键词：PRION AMYLOID NEURODEGENERATIVE disease Protein structure FOURIER-TRANSFORM infrared spectroscopy 
易碎的Prions反而更容易感染其它蛋白
《基础医学与临床》2006年第8期881-881,共1页
据美国BIOCOMPARE科技新闻网（2006／7／3）报道，易碎性的东西往往暗示其很脆弱，但对Prions而言却恰恰相反。UCSF（University of Califomia，SanFrancisco）Howard医学院的研究人员发现Prions蛋白断裂的部分，可作为感染其它正常蛋...
关键词：蛋白 感染 科技新闻 研究人员 《自然》 易碎性 医学院 
Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease被引量：9
《World Journal of Gastroenterology》2005年第48期7651-7656,共6页Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan 
Supported by Bavarian Ministry of Health, Germany
AIM： Pathological prion protein （PrP^sc） is responsible for the development of transmissible spongiform encephalopathies （TSE）. While PrPc enters the organism via the oral route, less data is available to know ab...
关键词：PRIONS Helicobacter pylori  Gastrin Proinflammatory cytokines 
Preparation of Monoclonal Antibodies Against Prion Proteins With Full-length Hamster PrP被引量：1
《Biomedical and Environmental Sciences》2005年第4期273-280,共8页XIN-LI XIAO HUI-YING JIANG JIN ZHANG JUN HAN KAI NIE XIAO-BO ZHOU YIN-XIA HUANG LAN CHEN WEI ZHOU BAO-YUN ZHANG YONG LIU XIAO-PING DONG 
ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina30070038and30130070,NationalHigh-techDevelopmentProject(863Project)2001AA215391,andEUProjectQLRT200001441.
To prepare the PrP specific monoclonal antibodies （mAbs） that can be used for the detection of mammalian prions and study of pathogenesis of prion diseases. Methods Several BALB/c mice were immunized with recombinan...
关键词：PRIONS Hamster prion protein Monoclonal antibodies 
Prions朊病毒的研究进展被引量：2
《中山大学研究生学刊（自然科学与医学版）》2003年第4期20-29,共10页林键 
朊病毒(Proteinaceous Infectious Particales简称Prions)病是一种人和动物共患的亚急性海绵状脑病,其病原是一种具有传染性的不含核酸的病原体,故称为感染性朊病毒蛋白(PrP)。但它是如何复制成为异常PrPSc,并沉积在脑组织而引起发病,...
关键词：朊病毒 PRIONS 亚急性海绵状脑病 病原体 感染性朊病毒蛋白 发病机制 预防措施 治疗方案 克-雅氏病 PRP 
Protein-only" or "virino" in prion diseases?被引量：2
《Chinese Science Bulletin》2000年第3期285-288,共4页YANG Chiming (Chi Ming Yang) & CHEN Yi1. Institute for Life Science and Health at UCSD, P.O.Box 12035, La Jolla, CA 92039, USA 2. Institute of Chemistry, Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Yang Chiming 
60-year prion and scrapie research has led to a dilemma in understanding the unknown aetiology of the infectious neurodegenerative disorders with intriguing features. Current progress and dilemma in prion research are...
关键词：PRIONS MAD COW disease NEURODEGENERATIVE disorder subviral PATHOGEN PRION radical. 
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