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Targeting mixed lineage kinase domain-like protein's nonnecroptosis role:A new horizon in anti-inflammatory therapy for alcoholic liver disease
《World Journal of Gastroenterology》2025年第13期158-162,共5页Yue Xi Dong Guo Shi Li Jie-Yu Guo Xing-Zhen Chen Jing-Feng Tang Ce-Fan Zhou 
Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yu...
关键词：Mixed lineage kinase domain-like protein ATP-binding pocket CPD4 inhibitor Alcoholic liver disease Therapeutic targets Liver diseases 
Mixed lineage kinase domain-like protein in liver diseases:Cell-typespecific functions and dual roles
《World Journal of Gastroenterology》2025年第14期161-167,共7页Ming-Xing Liang Ying Zhou Su-Qun Li Wan-Sheng Xiang Zong-Qin Pan Ying-Hua Chen Yi-Huai He 
Supported by the Science and Technology Planning Projects of Guizhou Province,No.QKHJC-ZK[2022]YB642;Health Research Project of Guizhou Province,No.gzwkj2024-324,and No.gzwkj2024-103;WBE Liver Fibrosis Foundation,No.CFHPC2025028;Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-Rgg018;Student Innovation and Entrepreneurship Training Program of Zunyi Medical University,No.S2024106612360.
In this letter,we comment on the article by Xuan Yuan et al,published in the recent issue of the World Journal of Gastroenterology.Mixed lineage kinase domainlike protein(MLKL)exhibits cell-type-specific functions in ...
关键词：Cell-type-specific functions Dual roles Liver diseases Mixed lineage kinase domain-like protein NECROPTOSIS 
Ras-related protein Rab24 plays a predictive role in hepatocellular carcinoma and enhanced tumor proliferation
《World Journal of Gastroenterology》2025年第8期115-129,共15页Han Ding Zhi-Guo Ding Song Liu Xu-Nan Mao Xing-Sheng Lu 
BACKGROUND Ras-related protein Rab24,which belongs to the small GTPase family,plays a crucial role in regulating intracellular protein trafficking.Dysregulation of Rab24 has been recently identified in hepatocellular ...
关键词：Hepatocellular carcinoma Ras-related protein Rab24 Prognosis Proliferation 
Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway
《World Journal of Gastroenterology》2025年第6期44-61,共18页Han-Ning Xuan Yuan Hyun Sung Kim Gye Ryeol Park Jae Eun Ryu Ji Eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun 
Supported by the National Research Foundation of Korea Grant Funded by the Korea Government,No.RS-2024-00440477;the Korea Institute of Science and Technology Institutional Program,No.2E33111-24-042.
BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver diseases.This study aims to specifically investigate the rol...
关键词：RAW 264.7 cell Cell death NECROPTOSIS Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease 
Tumor-related factor complement Clq/TNF-related protein 6 affects the development of digestive system tumors through the phosphatidylinositol 3-kinase pathway
《World Journal of Gastroenterology》2024年第26期3206-3209,共4页Mo-Wei Kong Xin-Rui Li Yu Gao Ting-Fang Yang 
In this editorial,we review the work of Razali et al published in World J Gas-troenterology,with a particular focus on the effect of rs10889677 variation in the phosphatidylinositol 3-kinase(PI3K)pathway and buparlisi...
关键词：Phosphatidylinositol 3-kinase Complement Clq/TNF-related protein 6 Gastric cancer Colorectal cancer Tumor-related factor 
F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit被引量：1
《World Journal of Gastroenterology》2023年第28期4433-4450,共18页Zhi Liu Ning-Yuan Chen Zhao Zhang Sai Zhou San-Yuan Hu 
the National Natural Science Foundation of China,No.82070869 and 82270914.
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a major health burden with an increasing global incidence.Unfortunately,the unavailability of knowledge underlying NAFLD pathogenesis inhibits effective preventive...
关键词：F-box only protein 2 Nonalcoholic fatty liver disease The hydroxyl CoA dehydrogenase alpha subunit Liver steatosis Ubiquitination Lipid accumulation 
Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor
《World Journal of Gastroenterology》2023年第26期4200-4213,共14页Wen-Zhi Qu Luan Wang Juan-Juan Chen Yang Wang 
Natural Science Foundation of Liaoning Province,No.2020-MS-148。
BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract.Tyrosine kinase inhibitors,such as imatinib,have been used as first-line therapy for the treatment ...
关键词：Raf kinase inhibitory protein Phosphorylated extracellular-signal-regulated kinase Gastrointestinal stromal tumors IMMUNOHISTOCHEMISTRY Survival analysis Risk grade model 
Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways被引量：1
《World Journal of Gastroenterology》2023年第18期2798-2817,共20页Liu Shi Li Zhou Ming Han Yu Zhang Yang Zhang Xiao-Xue Yuan Hong-Ping Lu Yun Wang Xue-Liang Yang Chen Liu Jun Wang Pu Liang Shun-Ai Liu Xiao-Jing Liu Jun Cheng Shu-Mei Lin 
the National Key Research and Development Program of China,No.2017YFC0908104;National Science and Technology Projects,No.2017ZX10203201,No.2017ZX10201201,and No.2017ZX10202202.
BACKGROUND Hepatic fibrosis is a serious condition,and the development of hepatic fibrosis can lead to a series of complications.However,the pathogenesis of hepatic fibrosis remains unclear,and effective therapy optio...
关键词：Nonstructural protein 3-transactivated protein 1 CALCITRIOL Liver fibrosis Hepatic stellate cells Mouse model TGFβ1/Smad3 NF-κB Signaling pathway 
Dickkopf-related protein 1/cytoskeleton-associated protein 4 signaling activation by Helicobacter pylori-induced activator protein-1 promotes gastric tumorigenesis via the PI3K/AKT/mTOR pathway被引量：2
《World Journal of Gastroenterology》2022年第47期6769-6787,共19页Mei Luo Yuan-Jia Chen Yuan Xie Qin-Rong Wang Yi-Ning Xiang Ni-Ya Long Wen-Xiu Yang Yan Zhao Jian-Jiang Zhou 
the National Natural Science Foundation of China,No.32160166,No.31760328,and No.31960028;Natural Science Foundation of Guizhou Province,No.ZC[2020]4Y026,No.JC[2020]1Z010,No.JC[2020]1Y333,and No.ZK[2022]041;Scientific Research Project of Guizhou Medical University,No.20NSP068.
BACKGROUND Gastric cancer(GC)is a common malignant tumor with high incidence and mortality rates globally,especially in East Asian countries.Helicobacter pylori(H.pylori)infection is a significant and independent risk...
关键词：Gastric cancer Helicobacter pylori Dickkopf-related protein 1 Cytoskeleton-associated protein 4 Phosphatidylinositol 3-kinase pathway 
Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation被引量：5
《World Journal of Gastroenterology》2022年第4期479-496,共18页Fang Xiao Hong-Wu Wang Jun-Jian Hu Ran Tao Xin-Xin Weng Peng Wang Di Wu Xiao-Jing Wang Wei-Ming Yan Dong Xi Xiao-Ping Luo Xiao-Yang Wan Qin Ning 
Supported by the National Science and Technology Major Project,No.2017ZX10202201;and the National Natural Science Foundation of China,No.NSFC 81700529。
BACKGROUND Heterogeneous macrophages play an important role in multiple liver diseases,including viral fulminant hepatitis(VFH).Fibrinogen-like protein 2(FGL2)is expressed on macrophages and regulates VFH pathogenesis...
关键词：Viral fulminant hepatitis Fibrinogen-like protein 2 Proinflammatory macrophages Infiltrating macrophages P38 
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