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Mutation in a non-force-bearing region of protein L influences force-dependent unfolding behavior: 《Chinese Physics B》2024年第7期624-629,共6页蒋环杰王艳伟陈家媛胡丹潘海郭子龙陈虎; supported by the National Natural Science Foundation of China(Grant Nos.12174322 to HC and 12204124 to ZG);111 Project(Grant No.B16029);the Graduate Scientific Research Foundation of Wenzhou University(Grant No.3162023003034 to JH);research grant from Wenzhou Institute。; Single-molecule magnetic tweezers(MTs) have revealed multiple transition barriers along the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we utilized MTs to measure the force-dep...; 关键词：protein folding magnetic tweezers protein L

Effect of chaperone–client interaction strength on Hsp70-mediated protein folding: 《Chinese Physics B》2023年第11期635-641,共7页邹禄军陆伽俊徐秀莲; Project supported by the National Natural Science Foundation of China (Grant Nos. 11305139 and 11974173);the HPC Center of Nanjing University。; Protein folding in crowding cellular environment often relies on the assistance of various chaperones. Hsp70 is one of the most ubiquitous chaperones in cells. Previous studies showed that the chaperone–client intera...; 关键词：protein folding molecular chaperone molecular dynamics HSP70

Equilibrium folding and unfolding dynamics to reveal detailed free energy landscape of src SH3 protein by magnetic tweezers被引量：2: 《Chinese Physics B》2021年第7期595-599,共5页Huanhuan Su Hao Sun Haiyan Hong Zilong Guo Ping Yu Hu Chen; the National Natural Science Foundation of China(Grant Nos.11874309 and 11474237);the 111 Project(Grant No.B16029)。; Src SH3 protein domain is a typical two-state protein which has been confirmed by research of denaturant-induced unfolding dynamics.Force spectroscopy experiments by optical tweezers and atomic force microscopy have m...; 关键词：protein folding and unfolding magnetic tweezers free energy landscape transition state

Folding nucleus and unfolding dynamics of protein 2GB1: 《Chinese Physics B》2021年第2期116-120,共5页Xuefeng Wei Yanting Wang; Project supported by the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDA17010504);the National Natural Science Foundation of China(Grant No.11947302)。; The folding of many small proteins is kinetically a two-state process with one major free-energy barrier to overcome,which can be roughly regarded as the inverse process of unfolding.In this work,we first use a Gaussi...; 关键词：protein folding 2GB1 two-state model folding nucleus

Application of topological soliton in modeling protein folding: Recent progress and perspective被引量：1: 《Chinese Physics B》2020年第10期24-32,共9页Xu-Biao Peng Jiao-Jiao Liu Jin Dai Antti J Niemi Jian-Feng He; Proteins are important biological molecules whose structures are closely related to their specific functions. Understanding how the protein folds under physical principles, known as the protein folding problem, is one...; 关键词：protein folding coarse-grained method Landau free energy function topological soliton

Different potential of mean force of two-state protein GB1 and downhill protein gpW revealed by molecular dynamics simulation: 《Chinese Physics B》2020年第7期99-103,共5页Xiaofeng Zhang Zilong Guo Ping Yu Qiushi Li Xin Zhou Hu Chen; Project supported by the National Natural Science Foundation of China(Grant Nos.11874309,11474237,and 11574310);the 111 Project,China(Grant No.B16029).; Two-state folding and down-hill folding are two kinds of protein folding dynamics for small single domain proteins.Here we apply molecular dynamics(MD)simulation to the two-state protein GB1 and down-hill folding prot...; 关键词：protein folding molecular dynamics simulation umbrella sampling potential of mean force

Quantum intelligence on protein folding pathways: 《Chinese Physics B》2020年第1期107-112,共6页Wen-Wen Mao Li-Hua Lv Yong-Yun Ji You-Quan Li; Project supported by the National Key Research and Development Program of China(Grant No.2017YFA0304304);the National Natural Science Foundation of China(Grant No.11935012); We study the protein folding problem on the base of our quantum approach by considering the model of protein chain with nine amino-acid residues.We introduce the concept of distance space and its projections on a XY-p...; 关键词：protein folding quantum walk shortest pathways mean first passage time

Proteins:From sequence to structure被引量：2: 《Chinese Physics B》2014年第7期107-113,共7页郑伟谋; supported by the National Natural Science Foundation of China (Grant Nos. 11175224 and 11121403); Protein sequences as special heterogeneous sequences are rare in the amino acid sequence space. The specific sequen- tial order of amino acids of a protein is essential to its 3D structure. On the whole, the correlati...; 关键词：PROTEINS protein sequence protein structures protein folding

Structure optimization by heuristic algorithm in a coarse-grained off-lattice model: 《Chinese Physics B》2009年第6期2615-2621,共7页刘景发; Project supported by the Foundation of Nanjing University of Information Science and Technology;the Excellent Youth Foundation of Education Office of Hunan Province,China (Grant No 07B009); A heuristic algorithm is presented for a three-dimensional off-lattice AB model consisting of hydrophobic （A） and hydrophilic （B） residues in Fibonacci sequences. By incorporating extra energy contributions into t...; 关键词：protein folding off-lattice model HEURISTICS FCC-lattice

Protein structural codes and nucleation sites for protein folding: 《Chinese Physics B》2007年第2期392-404,共13页江凡李南; One of the long-standing controversial arguments in protein folding is Levinthal＇s paradox. We have recently proposed a new nucleation hypothesis and shown that the nucleation residues are the most conserved sequence...; 关键词：NUCLEATION hydrogen bond secondary structure structural code protein folding sequence-structure relationship

PROTEIN_FOLDING