PTP1B

作品数：181被引量：572H指数：11
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相关领域：医药卫生更多>>
相关作者：叶菲田金英吴丽娟王树林李英俊更多>>
相关机构：中国科学院辽宁师范大学中国医学科学院北京协和医学院吉林大学更多>>
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相关基金：国家自然科学基金国家高技术研究发展计划辽宁省自然科学基金山西省自然科学基金更多>>
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Valeriaquinone A,a unique anthraquinone–coumarin hybrid with selective inhibition of PTP1B from Knoxia valerianoides
《Chinese Chemical Letters》2022年第6期2919-2922,共4页Yan Jiang Ren-Yong Yang Zhao-Xia Qu Gui-Ge Hou Wei Cong Chun-Hua Wang Feng Zhao 
National Natural Science Foundation of China(No.81703391);Shandong Provincial Natural Science Foundation of China(No.ZR2020KB015);Key R&D Program of Shandong Province(No.2019JZZY011104,China)。
Valeriaquinone A(1),an unprecedented anthraquinone–coumarin hybrid,was isolated from the roots of Knoxia valerianoides.Its structure was determined by extensive spectroscopic analyses and X-ray diffraction.The plausi...
关键词：Knoxia valerianoides Anthraquinone–coumarin hybrid PTP1B inhibitory activity Cytotoxic activity Allosteric inhibition 
5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities被引量：2
《Chinese Chemical Letters》2017年第6期1190-1193,共4页Duo-Qing Xue Hai-Li Liu Si-Han Chen Ernesto Mollo Margherita Gavagnin Jia Li Xu-Wen Li Yue-Wei Guo 
financially supported by the National Natural Science Foundation of China(Nos.41476063,81520108028,81273430,41306130 81302692,41676073,81603022);SCTSM Project from Shanghai Science and Technology Committee,Shanghai,China(Nos.14431901100,15431901000);The project from Institutes for Drug Discovery and Development,Chinese Academy of Sciences,China(No.CASIMM0120152039);the SKLDR/SIMM Projects from Shanghai Institute of MateriaMedica,China(No.SIMM 1501ZZ-03);support of "Youth Innovation Promotion Association"(No.2016258) from Chinese Academy of Sciences;"Young Talent Supporting Project" from China Association for Science and Technology(No.2016QNRC001);Shanghai "Pujiang Program"(No.16PJ1410600)
Two new 5-alkylpyrrole-2-carboxaldehyde derivatives,mycalenitrile-15（1） and mycalenitrile-16（2）,along with five known related ones（3-7）,were isolated from the South China Sea sponge Mycale lissochela.The structu...
关键词：5-Alkylpyrrole-2-carboxaldehyde Sponge Mycale lissochela PTP1B inhibitor Marine natural product 
Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors被引量：4
《Chinese Chemical Letters》2010年第12期1415-1418,共4页Yuan Feng Tong Pei Zhang Feng Chen Ling Hua Hao Fei Ye Jin Ying Tian Song Wu 
Financial support was provided by the National Natural Science Funds for Young Scholar(No.30901841);the Research Fund for the Doctoral Program of Higher Education of China(No.200800231145);the Major Scientific and Technological Special Project for"Significant New Drugs Innovation"(No.2009ZX09301-003).
Based on the fact that petroselinic acid showed good inhibitory activity（IC50 = 6.99μmol/L） against protein tyrosine phophatase 1B（PTP1B） in vitro,a series of novel N-（alkoxyphenyl）-aminocarbonylbenzoic acid de...
关键词：Petroselinic acid PTP1B N-（Alkoxyphenyl）-aminocarbonylbenzoic acid derivatives SYNTHESIS Diabetes 
Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity被引量：2
《Chinese Chemical Letters》2007年第11期1323-1326,共4页Hong Gang Hu Ming Juan Wang Qing Jie Zhao Shi Chong Yu Chao Mei Liu Qiu Ye Wu 
Protein tyrosine phosphatase 1 B （PTP1 B） has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic a...
关键词：MANGIFERIN Protein tyrosine phosphatase 1B Dedvates INHIBITION 
Anti-diabetes Agents——I:Tetralone Derivative from Juglans regia被引量：4
《Chinese Chemical Letters》2003年第5期489-490,共2页Tian Ying AN Li Hong HU Rong Min CHEN Zhong Liang CHEN Jia LI Qiang SHEN 
A new compound, 4-hydroxy-a-tetralone-4-O-b-D-[6-O-(3,4,5-trihydroxybenzoyl) glucopyranoside (1), together with a known compound, 4-hydroxy-a-tetralone (2), has been isolated from the roots of Juglans regia. 2 showed...
关键词：Juglans regia JUGLANDACEAE TETRALONE PTP1B inhibitor. 
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