This work was supported in part by grants from the National Key Research and Development Program of China (No 2017YFA0505200), the National Basic Research Program of China (973 Program) (No 2015CB910403), the National Natural Science Foundation of China (No 21602133, 81570118, 81570112), and the Science and Technology Committee of Shanghai (No 15401901800 and 13ZR1456900).
Deubiquitinating protease USP7 is a promising therapeutic target for cancer treatment, and interest in developing USP7 inhibitors has greatly increased. In the present study, we reported a series of natural pentacycli...