supported by the National Natural Science Foundation of China,Nos.82204360(to HM)and 82270411(to GW);National Science and Technology Innovation 2030 Major Program,No.2021ZD0200900(to YL)。
Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0...
Initially,the Sigma-1 receptor(S1R)was incorrectly categorized as one of the opioid receptors.But it has since become clear that S1R is a non-opioid non-phencyclidine receptor with molecular chaperone activity.S1R is ...
supported by Japan Society for the Promotion of Science KAKENHI(JP16K18888,to KT)
The sigma receptor (Sig-R) was first reported by Martin et al.(1976) and was initially classified into the opioid receptor family. However, Sig-R was subsequently found to differ from the opioid receptor in various st...
Chemotherapy-induced peripheral neuropathy is a very frequent neurological complication in cancer. Oxaliplatin(OXA) is a platinum analogue used as a first-line agent in the treatment of colorectal cancer. OXA induce...
Oxidative stress plays a major role in neurodegenerative disease since central nervous system is particularly vul- nerable to reactive oxygen species (ROS) due to several reasons: high consumption ROS and nitrosati...
supported by grants to M.A.C.from the Michael J Fox Foundation for Parkinson’s Research;the Swedish Parkinson Foundation;The Swedish Research Council(project no.K201261X-13480-13-5);European Community’s Seventh Framework Programme FP7/2008 under grant agreement no.215618(project acronym,Neuromodel);the Basal Ganglia Disorders Linnaeus Consortium(BAGADILICO);Greta and Johan Kocks Foundation;hlen Foundation
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by typical motor signs and symptoms that are due to dopamine (DA) depletion in the basal ganglia. The treatment of PD is symptom...
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) are common types of mitochondrial encephalomyopathy. The involved muscular pathology is characterized by typical changes of mitochon...