SIG

作品数:549被引量:563H指数:13
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  • 期刊=Neural Regeneration Researchx
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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation被引量:1
《Neural Regeneration Research》2025年第8期2325-2336,共12页Yafan Bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li 
supported by the National Natural Science Foundation of China,Nos.82204360(to HM)and 82270411(to GW);National Science and Technology Innovation 2030 Major Program,No.2021ZD0200900(to YL)。
Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0...
关键词:antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury 
Sigma-1 receptor: culprit and rescuer in motor neuron diseases
《Neural Regeneration Research》2021年第1期106-107,共2页Jean-Charles Liévens Tangui Maurice 
Initially,the Sigma-1 receptor(S1R)was incorrectly categorized as one of the opioid receptors.But it has since become clear that S1R is a non-opioid non-phencyclidine receptor with molecular chaperone activity.S1R is ...
关键词:ORGANS OPIOID SIGMA 
Sigma-2 receptor as a potential therapeutic target for treating central nervous system disorders
《Neural Regeneration Research》2019年第11期1893-1894,共2页Kazuki Terada Keisuke Migita Yukari Matsushima Chiaki Kamei 
supported by Japan Society for the Promotion of Science KAKENHI(JP16K18888,to KT)
The sigma receptor (Sig-R) was first reported by Martin et al.(1976) and was initially classified into the opioid receptor family. However, Sig-R was subsequently found to differ from the opioid receptor in various st...
关键词:SIGMA receptor(Sig-R) MARTIN Sigma-2 
Sigma-1 receptor: a new player in neuroprotection against chemotherapy-induced peripheral neuropathy被引量:1
《Neural Regeneration Research》2018年第5期775-778,共4页Jordi Bruna Roser Velasco 
Chemotherapy-induced peripheral neuropathy is a very frequent neurological complication in cancer. Oxaliplatin(OXA) is a platinum analogue used as a first-line agent in the treatment of colorectal cancer. OXA induce...
关键词:OXALIPLATIN chemotherapy-induced peripheral neuropathy sigma-1 receptor NEUROTOXICITY MR309 E-52862 
Sigma-1 receptor and neuroprotection:current outlook and potential therapeutic effects
《Neural Regeneration Research》2016年第9期1392-1393,共2页Giovanni Li Volti Paolo Murabito 
Oxidative stress plays a major role in neurodegenerative disease since central nervous system is particularly vul- nerable to reactive oxygen species (ROS) due to several reasons: high consumption ROS and nitrosati...
关键词:MCAO Sigma-1 receptor and neuroprotection 
Sigma-1 receptor:a potential new target for Parkinson's disease?
《Neural Regeneration Research》2014年第21期1882-1883,共2页Veronica Francardo 
supported by grants to M.A.C.from the Michael J Fox Foundation for Parkinson’s Research;the Swedish Parkinson Foundation;The Swedish Research Council(project no.K201261X-13480-13-5);European Community’s Seventh Framework Programme FP7/2008 under grant agreement no.215618(project acronym,Neuromodel);the Basal Ganglia Disorders Linnaeus Consortium(BAGADILICO);Greta and Johan Kocks Foundation;hlen Foundation
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by typical motor signs and symptoms that are due to dopamine (DA) depletion in the basal ganglia. The treatment of PD is symptom...
关键词:Sigma-1 receptor PARK 
Myopathological features in MELAS syndrome without significant changes in muscle biopsy pathology
《Neural Regeneration Research》2010年第21期1673-1677,共5页Pu Fang Chengsi Wu Meihong Zhou Renshi Xu Xianhua Liu Caixia Wei 
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) are common types of mitochondrial encephalomyopathy. The involved muscular pathology is characterized by typical changes of mitochon...
关键词:mitochondrial encephalomyopathy  lactic acidosis  and stroke-like episodes syndrome muscle biopsy NEUROIMAGING PATHOLOGY 
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