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Effects of MgO nanoparticle addition on the mechanical properties,degradation properties,antibacterial properties and in vitro and in vivo biological properties of 3D-printed Zn scaffolds
《Bioactive Materials》2024年第7期72-85,共14页Leiting Yu Fengdong Sun Yuanyuan Wang Wei Li Yufeng Zheng Guangxin Shen Yao Wang Minfang Chen 
support for this work from the National Natural Science Foundation of China (Nos.52171241 and 52373251).
Bone tissue engineering is the main method for repairing large segment bone defects.In this study,a layer of bioactive MgO nanoparticles was wrapped on the surface of spherical Zn powders,which allowed the MgO nanopar...
关键词：3D printing Porous Skeletal-gyroid Zn/MgO scaffold BIOCOMPATIBILITY 
Macrophage-derived extracellular vesicles regulate skeletal stem/progenitor Cell lineage fate and bone deterioration in obesity
《Bioactive Materials》2024年第6期508-523,共16页Chen He Chen Hu Wen-Zhen He Yu-Chen Sun Yangzi Jiang Ling Liu Jing Hou Kai-Xuan Chen Yu-Rui Jiao Mei Huang Min Huang Mi Yang Qiong Lu Jie Wei Chao Zeng Guang-Hua Lei Chang-Jun Li 
supported by the National Key R&D Program of China(Grant 2022YFC3601900 to G.H.L.,2022YFC3601903,and 2022YFC3601905 to C.J.L.,2019YFA0111900 to Y.J.);the National Natural Science Foundation of China(Grant Nos.82261160397,82272560,81922017 to C.J.L.);the Hunan Provincial Science and Technology Department(2023JJ30896 to C.J.L.,2023JJ40965 to L.L.);the Key Research and Development Program of Hunan Province(2022SK2023 to C.J.L.);Science and Technology Innovation Program of Hunan Province(2023RC1027 to C.J.L.,2022RC1009 to J.W.,and 2022RC3075 to C.Z.);The NSFC/RGC Joint Research Scheme,the Research Grants Council(UGC)of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China(NSFC/RGC Project No.N_CUHK483/22 to Y.J.);the Center for Neuromusculoskeletal Restorative Medicine[CNRM at InnoHK,to Y.J.]by Innovation and Technology Commission(ITC)of Hong Kong SAR,China.
Obesity-induced chronic inflammation exacerbates multiple types of tissue/organ deterioration and stem cell dysfunction;however,the effects on skeletal tissue and the underlying mechanisms are still unclear.Here,we sh...
关键词：Obesity-induced bone deterioration Macrophage-derived extracellular vesicles Skeletal stem/progenitor cells Cell fate Aptamer Cell-specific targeting 
Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy
《Bioactive Materials》2024年第4期204-220,共17页Pei-Lin Li Da-Fu Chen Xiao-Tong Li Rui-Cong Hao Zhi-Dong Zhao Zhi-Ling Li Bo-Feng Yin Jie Tang Yu-Wen Luo Chu-Tse Wu Jing-Jun Nie Heng Zhu 
supported by the National Key R&D Program of China(Nos.2022YFA1104100,2022YFA1103500,2022YFB3804400);the National Natural Sciences Grants China(Nos.82172388,82372373,81871771,52373128,52273121);the Beijing Natural Sciences Foundation(Nos.7222123,L212065,7222011);the Beijing Municipal Health Commission(Nos.BMHC-2021-6,BJRITO-RDP-2023).
Skeletal stem cells(SSC)have gained attentions as candidates for the treatment of osteoarthritis due to their osteochondrogenic capacity.However,the immunomodulatory properties of SSC,especially under delivery operati...
关键词：Microgel carriers Skeletal stem cells Immunomodulation reprogram Single-cell RNA sequence Osteoarthritis 
A biomaterial-based therapy for lower limb ischemia using Sr/Si bioactive hydrogel that inhibits skeletal muscle necrosis and enhances angiogenesis被引量：2
《Bioactive Materials》2023年第8期264-278,共15页Ye Yuan Zhaowenbin Zhang Fandi Mo Chen Yang Yiren Jiao Enci Wang Yuchong Zhang Peng Lin Chengkai Hu Weiguo Fu Jiang Chang Lixin Wang 
supported by the National Natural Science Foundation of China(grant number:82270415);Key Project Fund of Natural Science Foundation of Fujian Science and Technology Department(grant number:2021GGB030);Shanghai Municipal Science and Technology Commission Innovation Fund(grant number:22S31904800);Fudan Zhangjiang Clinical Medicine Innovation Fund(grant number:KP7202115);Fujian Province Health Science and Technology Fund(grant number:2021GGB030);the National Natural Science Foundation of China(grant number:81970412);Medical-Industrial Cooperation Project of Zhongshan Hospital Affiliated to Fudan University(grant number:MP2021Q2C018);National Clinical Research Center for Interventional Medicine Fund(grant number:2021-004);Xiamen Municipal Health Science And Technology Program Fund(grant number:3502Z20194034);Zhongshan hospital’s Talents Supporting Plan(grant number:2019ZSGG11);Shanghai Municipal Science and Technology Commission Innovation Fund(grant number:18441902400).
Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic diseases.In this study,a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bi...
关键词：Hindlimb ischemic diseases Strontium carbonate and calcium silicate BIOCERAMIC Bioactive hydrogel Muscle necrosis ANGIOGENESIS 
Bone without borders-Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope
《Bioactive Materials》2023年第1期103-114,共12页Furqan A.Shah Martina Jolic Chiara Micheletti Omar Omar Birgitta Norlindh Lena Emanuelsson Håkan Engqvist Thomas Engstrand Anders Palmquist Peter Thomsen 
Calcium phosphates(CaP)represent an important class of osteoconductive and osteoinductive biomaterials.As proof-of-concept,we show how a multi-component CaP formulation(monetite,beta-tricalcium phosphate,and calcium p...
关键词：BONE Calcium phosphate Monetite Calcium pyrophosphate Electron microscopy Raman spectroscopy 
Corrigendum to“Injectable muscle-adhesive antioxidant conductive photothermal bioactive nanomatrix for efficiently promoting full-thickness skeletal muscle regeneration”[Bioact Mater,6(2021)1605-1617]被引量：1
《Bioactive Materials》2021年第12期4319-4320,共2页Li Zhou Juan Ge Min Wang Wei Cheng Wenchen Ji Bo Lei 
The authors regret that the fluorescent image for FPC-7day in Figure 5A was reproduced incorrectly,although which did not affect the conclusion of this work.
关键词：Cor SKELETAL FIGURE 
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