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Somatic CDKN2A copy number variations are associated with the prognosis of esophageal squamous cell dysplasia
《Chinese Medical Journal》2024年第8期980-989,共10页Zhiyuan Fan Jing Zhou Yuan Tian Yu Qin Zhaojun Liu Liankun Gu Sanford M.Dawsey Wenqiang Wei Dajun Deng 
Beijing Natural Science Foundation(No.7181002);Capital’s Funds for Health Improvement and Research(No.2018-1-1021);National Key Research&Development Program of China(No.2016YFC0901404)
Background:Somatic copy number variations(SCNVs)in the CDKN2A gene are among the most frequent events in the dysplasia-carcinoma sequence of esophageal squamous cell carcinoma.However,whether CDKN2A SCNVs are useful b...
关键词：Somatic copy number variations Esophageal squamous cell carcinoma Esophageal neoplasms Squamous intraepithelial lesions DNA copy number variations PROGNOSIS Prospective study 
Single-cell profiling of the copy-number heterogeneity in colorectal cancer
《Chinese Medical Journal》2023年第6期707-718,共12页Shiyu Song Lin Feng Kexing Xi Zhigang Sun Deyang Kong Zhenkai Luo Wei Pei Haizeng Zhang 
Background:With functionally heterogeneous cells,tumors comprise a complex ecosystem to promote tumor adaptability and evolution under strong selective pressure from the given microenvironment.Diversifying tumor cells...
关键词：Somatic copy number alteration Microsatellite stable Colorectal cancer Single cell RNA-sequencing Intra-tumor genetic heterogeneity 
Identification and characterization of murine adipose tissue-derived somatic stem cells of Shenque(CV8)acupoint被引量：4
《Chinese Medical Journal》2021年第22期2730-2737,共8页Yu-Hui Hao Zhi-Zhen Liu Hong Zhao Lei Wang Ajab Khan Jian-Bin Mu Yu-Fei Wang Li-Hong Yang Ran Zhou Jun Xie 
the National Natural Science Foundation Projects(No.81671462);Shanxi Natural Science Foundation Projects(No.201901D211315 and 201901D111184);Science and Technology Develop-ment Program of Xinzhou(No.20180103).
Background:Shenque(CV8)acupoint is located on the navel and has been therapeutically used for more than 2000 years in Traditional Chinese Medicine(TCM).However,clinical research on the underlying therapeutic molecular...
关键词：Shenque(CV8)acupoint Non-acupoint site NAVEL Adipose tissue Somatic stem cells Stem cell antigen-1(Sca-1) Umbilical therapy 
Sex discrepancy characterization revealed by somatic DNA alterations in muscle-invasive bladder carcinoma
《Chinese Medical Journal》2019年第20期2492-2494,共3页Tian-Zhi Wu Cheng-Yong Lei Jin-Ming Li Yan-Fang Guo 
the grants from the National Natural Science Foundation of China(No.81302228);the Foundation for Outstanding Young Teachers'Project in Colleges and Universities of Guangdong Province(No.YQ2015033).
To the editor: Bladder cancer exhibits significant sex differences in incidence, diagnosis, management, and survival.[1] The incidence of bladder cancer in males is approximately three-fold higher than that in females...
关键词：BLADDER alterations prognosis 
Changes in the Bispectral Index in Response to Loss of Consciousness and No Somatic Movement to Nociceptive Stimuli in Elderly Patients被引量：8
《Chinese Medical Journal》2016年第4期410-416,共7页Ning Yang Yun Yue Jonalhan Z Pan Ming-Zhang Zuo Yu Shi Shu-Zhen Zhou Wen-Ping Peng Jian-Dong Gao 
Background： Bispectral index （BIS） is considered very useful to guide anesthesia care in elderly patients, but its use is controversial for the evaluation of the adequacy of analgesia.This study compared the BIS ch...
关键词：Bispectral Index ELDERLY Nociceptive Stimuli PROPOFOL REMIFENTANIL 
Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia： The Research on East Asian Psychotropic Prescription Patterns Study
《Chinese Medical Journal》2015年第7期853-858,共6页Chao Chen Tian-Mei Si Yu-Tao Xiang Gabor S Ungvari Chuan-Yue Wang Yan-Ling He Ee-Heok Kua Senta Fuji Kang Sim Jitendra K Trivedi Eun-Kee Chung Pichet Udomratn Kok-Yoon Chee Norman Sartorius Chay-Hoon Tan Naotaka Shinfuku 
Background： Depression is often comorbid with chronic somatic diseases. Few previous studies have investigated the prevalence of somatic diseases in depression or the prescription pattern of antidepressants in comorb...
关键词：ASIA DEPRESSION PRESCRIPTION PREVALENCE Somatic Comorbidity 
Different sensitivities to rocuronium of the neuromuscular junctions innervated by normal/damaged facial nerves and somatic nerve in rats： the role of the presynaptic acetylcholine quantal release被引量：2
《Chinese Medical Journal》2012年第10期1747-1752,共6页CHEN Jun-liang LI Shao-qin CHI Fang-lu CHEN Lian-hua LI Shi-tong 
The study was supported by a grant from tt（e National Natural Science Foundation of China （No. 30872428）.
Background Muscles present different responses to muscle relaxants, a mechanism of importance in surgeries requiring facial nerve evoked electromyography under general anaesthesia. The non-depolarizing muscle relaxant...
关键词：rocuronium  pre-synaptic acetylcholine  quantal release facial nerve 
IN VIVO SOMATIC GENE TRANSFER WITH IkB AND TRUNCATED JUN DEPENDENCE OF TNF MEDIATED INTRAVASCULAR FIBRIN FORMATION ON NFkB AND AP-1
《Chinese Medical Journal》1995年第3期82-82,共1页Y Zhang Y Deng Th Luther M Muller B Chen R Ziegler PP Nawroth 
Recently it has been shown that induction of tissue factor (TF) by TNF in vitro is dependent on a concerted action of NFkB and AP-1. However it remains unknown, if TF can mediate intravascular fibrin formation and if ...
关键词：TNF TF NFKB IN VIVO SOMATIC GENE TRANSFER WITH IkB AND TRUNCATED JUN DEPENDENCE OF TNF MEDIATED INTRAVASCULAR FIBRIN FORMATION ON NFkB AND AP-1 AP 
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